万卫星 周翔 陈正平 纪书仁 尤徐阳 叶万忠 214063 无锡，核医学国家重点实验室、江苏省原子医学研究所 中华核医学杂志 1999 0 19 1


    关键词：柠檬酸盐类；锝；同位素标记；炎症；动物；实验 期刊 zhhyxzz 0 论著 fur -->


    

【摘要】 目的 研制炎症显像剂⁹⁹ Tc^m -柠檬酸盐(citrate)。方法 柠檬酸三钠在还原剂氯化亚锡存在,pH值6.0时与⁹⁹ Tc^m 络合，生成⁹⁹ Tc^m -citrate。研究了标记物的稳定性、炎症模型小白鼠体内分布并进行了炎症模型大白兔显像。结果 制备的⁹⁹ Tc^m -citrate标记率大于90%,6h内稳定。小白鼠炎症组织与正常组织的放射性比值高，注射后5、30、60、120min分别为0.97、3.18、4.76和3.32。⁹⁹ Tc^m -citrate主要经肾脏排泄,血液清除快。兔显像表明：注射后30、60、120、240min，炎症部位与对侧正常组织放射性比值分别为2.30、2.68、3.40和3.31。结论 ⁹⁹ Tc^m -citrate是一种有效灵敏的炎症灶显像剂,且制备方便。

    The preparation and animalstudy of an inflammation tracer, ⁹⁹ Tc^m -citrate

WAN Weixing, ZHOU Xiang, CHEN Zhengping, etal. State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063

【Abstract】 Objective Toprepare ⁹⁹ Tc^m -citrate, an inflammation tracer. Methods Using Sn(Ⅱ) as reducing agent, sodium citrate was complexed with ⁹⁹ Tc^m at pH 6.0. The stability of yielded complex, ⁹⁹ Tc^m -citrate andits biodistribution in mice model were studied.⁹⁹ Tc^m -citratescintigraphy in rabbit model of inflammation was performed. Results Thelabelling rate was over 90%.⁹⁹ Tc^m -citrate was stable within 6hours at room temperature. The inflammatory tissue/normal tissue were 0.97, 3.18, 4.76 and3.32 at 5, 30, 60 and 120min after injection, respectively. The radioactivity clearancemainly occurred in the kidney, and the clearance from blood was rapid. Images acquiredfrom the rabbit model showed that the inflammatory/normal radioactivity ratio were 2.30,2.68, 3.40 and 3.31 at 30, 60, 120 and 240 min, respectively. Conclusions ⁹⁹ Tc^m -citrateis an effective and sensitive radiopharmaceutical for scintigraphy of inflammatorylesions, and it is easy to prepare.

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