克晓燕 贾廷珍 陈旭芳 张绍刚 贾学琴 王良绪 100083 北京，北京医科大学第三医院(克晓燕 贾廷珍 陈旭芳 贾学琴 王良绪)；北京医院放射科(张绍刚) 中华放射医学与防护杂志 1998 0 18 4


    关键词：医源性急性放射病；造血干细胞；全身照射G-CSF 期刊 zhfsyxyfhzz 0 人的放射病 fur -->


    

目的 观察医源性急性放射病的临床特点和治疗经验，为事故性放射病的救治提供依据。方法 观察17例经大剂量照射预处理的PBSCT患者外周血象、体温和症状。结果 照后第8～12天，WBC均值<1×10⁹ /L，未用G-CSF者白细胞持续此低值至13.3天，29%的患者体温>38.5℃，经无菌处理和强有力的抗感染治疗，患者均能平稳渡过骨髓抑制期而不出现典型的急性放射病极期表现。结论 回输自体外周血干细胞和应用G-GSF以缩短骨髓重建时间，严格实行全环境保护和及时、联合足量应用抗生素的原则是PBSCT患者能够顺利渡过放射病极期，较少合并症的关键。

Clinicalobservation of iatrogenic acute radiation sickness Ke Xiaoyan,Jia tingzhen,Chen Xufang,etal .The Third Hospital,Beijing Medical University,Bijing 100083,China.

    ObjectiveClinical observation of acute radiation sickness (ARS) induced by medical treatment inorder to accumulate clinical experience .Methods The changes ofperipheral blood indexes,temperature and clinical symptoms of 17 cases who were irradiatedwith 6.0-7.2Gy X-ray before peripheral blood stem cell transplantation(PBSCT)wereobserved. Results WBC count began to decrease to below 1×10⁹ /Lfrom 8th day after irradiation and maintained for at this level 4 days,or for 13.3 days ifthe patients did not receive G-CSF treatment.29.4% of patients'ran a temperature hightrthan 38.5 ℃.Aftertotal environment protection and vigorous antibiotictical treatment,all patients cansuccessfully pass through the period of bone marrow depression with no typical criticalphase of ARS. Conclusion Auto-peripheral blood stem cell reinfusion and G-GSF treatment to reduce the time span for recoustrution of bone marrow,total environmentprotection and combined antibiotic treatment are the key point of sucessful treatment of PBSCT.

     Key words Iatrogenic acute radiation syndrome Stem cells Total body irradiation G-CSF

随着骨髓及外周血干细胞移植治疗肿瘤和恶性血液病在我国的逐渐普及 ......

您现在查看是摘要页，全文长 16888 字符。