李立 冉江华 陆晓青 孙锋 唐继红 昆明医学院第二附属医院肝胆外科 昆明 650101 中国普外基础与临床杂志 2000 0 7 3


    关键词：阻塞性黄疸；手术；细胞因子 期刊 zgpwjcylczz 0 170-171 临床研究 fur -->


    

【摘要】 目的 探讨阻塞性黄 疸(阻黄)患者细胞因子的改变，从而揭示阻黄患者免疫功能的变化。方法 用ELISA方法检测36例阻塞性黄疸患者术前及术后可溶性白细胞介素Ⅱ受 体(sIL-2R)、肿瘤坏死因子(TNF-α)、白细胞介素Ⅵ(IL-6)及白细胞介素Ⅷ(IL-8)的水 平。结果 术前阻塞性黄疸患者的sIL-2R、TNF-α、IL -6及IL-8水平均明显高于正常人(P<0.01)； 解除胆道梗阻术后，各细胞因子水平 开始下降，至术后第14天接近正常水平。结论 解除黄疸 有助于患者免疫功能的恢复，联合检测细胞因子在阻塞性黄疸患者中具有重要的临床意义。

    【中图分类号 】 R657.4⁺ 3； R392.12 【文献标识码 】 A

     【文章编号】 1007-9424(2000)03-0170-02

THE CHANGE OF CELLULAR FACTOR IN PERIOPERATIVE

    PATIE NTS WITH OBSTRUCTIVE JAUNDICE

LI Li, RAN Jiang-hua, LU Xiao-qing, et al.

    ( Department of General Surgery, The Second Afffiliated Hospital,

    Kunming Medical College, Kunming 650101 )

【 Abstract 】 Objecti ve To study the change of immunologic function of the patient w ith obstructive jaundice. Methods The level of the sIL-2R, TNF- α , IL-6 and IL-8 in 36 cases of obstructive jau ndice before and after operation were measured. Results The l evel of the sIL-2R, TNF- α , IL-6 and IL-8 in 36 cases of obstructive jaundic e before operation was higher than normal control group (P < 0.01). It decr eased a fter the obstruction was removed, and it was close to normal control on 14th day after operation. Conclusion The result suggest that relief of jaundice could improve the immunologic function of the patient.

     【 Key words 】 Obstruction jaundice Operation Ce llular factor ▲

阻塞性黄疸因各种原因所致肝内外胆管梗阻 ......

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