黄显凯 韩本立 黄显凯 第三军医大学大坪医院普外科(重庆 400042)；韩本立 第三军医大学西南医院肝胆中心 中国普外基础与临床杂志 1999 0 6 3


    关键词：胆道感染；多形核白细胞；肝损害 期刊 zgpwjcylczz 0 基础与实验研究 fur -->


    

摘要 为探讨多形核白细胞(PMN)浸润在急性胆管炎肝损害中的作用，作者观察了急性胆管炎时肝脏PMN聚集与肝损害的关系。结果显示：急性胆管炎时大鼠肝组织PMN数量进行性增多，开始主要聚集在肝窦，12小时后穿越肝窦内皮细胞在肝细胞周围聚集并逐渐增多，肝细胞变性坏死，动物24小时存活率仅为40%。消耗循环PMN使肝脏功能损害得到明显改善，肝坏死面积减少，动物存活率提高。表明肝脏PMN浸润在胆道感染肝损害发生中具有重要作用。

    

POLYMORPHONUCLEAR AGGREGATION OF LEUKOCYTE INACUTE CHOLANGITIS AND ITS ROLE IN HEPATIC DAMAGE

Huang Xiankai, Han Benli.

    Department of General Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042

Abstract The mumber ofPolymorphonuclear leukocyte (PMN) in hepatic tissue increased in the rats with cholangitis, PMN infiltration was mainly in the hepatic sinus in the early stage; and PMNinfiltration presented around the hepatocytes 12 hours after infection. Degeneration andnecrosis of the hepatic cells was also observed in the rats with acute cholangitis. Only40 percent of the rats survived 24 hours after infection. Depletion of circulating PMNdecreased the damage and necrosis of hepatocytes and improving the survival rate of theinfected rats. The results suggest that PMN infiltration plays an important role inhepatic damage in acute cholangitis.

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