关键词:休克;创伤性;出血;受体;内啡肽;心血管系统;大鼠
摘 要 目的: 明确参与创伤失血性休克的发病过程的亚型阿片受体。方法: 观察创伤失血性休克后大鼠心脏μ、δ和κ阿片受体的变化及与血流动力学指标变化的关系;观察δ和κ阿片受体特异性拮抗剂对创伤失血性休克大鼠血流动力学指标的影响。结果: 创伤失血休克后,大鼠心脏δ和κ阿片受体数目明显升高,与血流动力学指标下降呈显著负相关。δ和κ阿片受体特异性拮抗剂可明显逆转创伤失血休克大鼠血流动力学指标的下降。结论: 心脏δ和κ阿片受体可能参与了创伤失血性休克的发病过程。
The changes of myocardial μ,δ and κ opioid receptors and its role in the cardiovascular depression in traumatic hemorrhagic shock in rats
LIU Liang-Ming,HU De-Yao,LU Ru-Quan,CHEN Hui-Sun,CHEN Yan,DAN Fei-Jun
Research Institute of Surgery,Daping Hospital,Third Military Medical University,Chongqing (400042)
Abstract AIM: To elucidate the subclass opioid receptors involved in the pathogenesis of traumatic hemorrhagic shock.METHODS: The relationship between the changes of myocardial μ ......
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