肝癌组织中TGF-b1、TGF-b1RⅡ和NF-kB的表达
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缪 林, 张锁林, 季国忠, 范志宁, 刘 政
转化生长因子b1;转化生长因子b1Ⅱ型受体;核转录因子-kB;肝细胞癌,缪林,季国忠,范志宁,刘政,张平,杨春,通讯作者,:,Expr
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缪林, 季国忠, 范志宁, 刘政, 张平, 杨春 , 南京医科大学第二附属医院消化科 江苏省南京市 210011
张锁林, 江苏省丹阳市人民医院消化科 江苏省丹阳市 212300
缪林, 男, 1966-04-22生, 1989年南京医科大学, 医学硕士, 副教授, 主要从事消化道肿瘤和消化内镜基础与临床研究.
江苏省教育厅自然科学基金资助, No. 02KJD320023
通讯作者 : 缪林, 210011, 江苏省南京市, 南京医科大学第二附属医院消化科. miaofrest@yahoo.com.cn
电话: 025-83062836
收稿日期: 2005-04-11 接受日期: 2005-04-27
Expression of TGF- b1, TGF-b1RII and NF-k B in hepatocellular carcinoma
Lin Miao, Suo-Lin Zhang, Guo-Zhong Ji, Zhi-Ning Fan, Zheng Liu, Ping Zhang, Chun Yang
Lin Miao, Guo-Zhong Ji, Zhi-Ning Fan, Zheng Liu, Ping Zhang, Chun Yang, Department of Gastroenterology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China
Suo-Lin Zhang, Department of Gastroenterology, Danyang People'S Hospital, Zhenjiang 212300, Jiangsu Province, China
Supported by Natural Science Foundation the Department of Education of Jiangsu Province, No.02KJD320023
Correspondence to: Lin Miao, Department of Gastroenterology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China. miaofrest@yahoo.com.cn
Received: 2005-04-11 Accepted: 2005-04-27
Abstract
AIM: To explore the expression of TGF-b1, TGF-b1RII and NF-kB in hepatocellular carcinoma (HCC) tiussues.
METHODS: Immunohistochemistry was used to detect the expression of TGF-b1, TGF-bRII and NF-kB protein in 30 HCC and the corresponding cancer-adjacent tissues. The expression of TGF-b1 mRNA was determined in 30 HCC and the corresponding cancer-adjacent tissues by in situ hybridization. Vascular endothelial cells were labeled with CD34 to observe the microvessel density (MVD). Then the relationships between TGF-b1 protein and MVD, TGF-b1RII protein and MVD, NF-kB and TGF-b1 protein as well as between TGF-b1 protein and mRNA were analyzed ......
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