【摘要】 目的 了解肺结核患者呼吸道标本中白色念珠菌的致病性并评价其分离的临床意义。 方法 对100株临床分离的呼吸道白色念珠菌进行蛋白酶测定，并从高、中、低蛋白酶活力菌株中分别选2株作血管内皮细胞的细胞毒力和粘附性测定。 结果 100株白色念珠菌全部检测出蛋白酶，其中高蛋白酶活力71株(71%);中等活力18株(18%)，低活力11株(11%);细胞毒力试验表明蛋白酶活力越高，粘附能力越强，蛋白酶活力与毒力呈正相关(r=0.9946，P<0.01);细胞粘附试验表明蛋白酶活力越高，粘附能力越强，蛋白酶活力与粘附性直接正相关(r=0.9944，P<0.01)。 结论 蛋白酶是白色念珠菌的重要毒力因子，蛋白酶活力可直接反映其毒力，蛋白酶活力与其粘附性直接相关，肺结核患者呼吸道标本中白色念珠菌具有一定的致病性，临床应密切关注。

    【关键词】 呼吸道;白色念珠菌;致病性

    Pathogenicity of candida albicans in respiratory tract specimen of patients with pulmonary tuberculosis

    XI Jia-ning，XIAWei-yi，CHEN Xiao-zheng.

    Aerospace Center Hospital，Beijing100039，China

    【Abstract】 Objective To study pathogenicity and clinical significance of candida albicans in respiratory tract specimen of patients with pulmonary tuberculosis.Methods Acid proteinase of100C.albicans strains were detected on milk-agar plate.According to different level of acid proteinase activity(high，middle，low)，6strains were se-lected to determine the cytotoxicity and adhensiveness by blood vessel endothelial cells.Results All of100strains were detected proteinase.There were71strains with high-proteinase-activity ......