【摘要】 目的 探讨检测原发性肝癌(HCC)血清可溶性细胞间粘附分子-1(sICAM-1)水平的临床价值。 方法 采用ELISA法同期检测了53例HCC患者血清sICAM-1及AFP的含量，并与肝脏良性肿瘤、慢性肝炎肝硬化及健康志愿者相比较。 结果 HCC患者血清sICAM-1含量均值为(1382.5±752.3)ng/ml，显著高于各对照组(P<0.01);而肝脏良性肿瘤、肝炎肝硬化及健康志愿者之间差异无显著性(P>0.05);HCC患者血清sICAM-1含量与肿瘤大小、有无包膜及转移状态有关(P<0.05)，而与肿瘤组织学分级、血清AFP水平无关(P>0.05)。 结论 sICAM-1在HCC发生发展过程中起重要作用，检测血清sICAM-1对于HCC的诊断有重要价值，并有助于判断HCC患者肿瘤侵袭转移状态及病情监测。

    【关键词】 原发性肝癌;细胞间粘附分子-1;肿瘤转移

    Clinical value of detecting the levels of serum intercellular adehesion molecule-1in hepatocellular carcinoma LIUXue-qiang，GE Xiao-hu，CHENHai-sheng，et al.Department of Surgery，The Chinese Traditional Medicine

    Hospital，Zhongshan City，Guangdong Province528400，China

    【Abstract】 Objective To evaluate the clinical value of detecting the levels of serum intercellular adehesion molecule-1in hepatocellular carcinoma.Methods The serum levels of sICAM-1in53patients with HCC and30controls were measured by using ELISA ......