【摘要】

    目的 探讨乳腺癌病理生物学特征对预后的影响。

    方法 回顾性分析1995年1月～2004年12月手术的704例女性乳腺癌病理生物学特征与预后的关系。全组均经病理学检查。寿命表法统计生存率。并作显著性检验。

    结果 全组5年生存率82.2%。各病理类型的5年生存率差异无显著性(P>0.05)；肿瘤的分布与淋巴结转移及预后无关；病理分期与预后呈负相关；肿瘤大小与腋淋巴结转移呈正相关，与生存率呈负相关；腋淋巴结阳性的5年生存率明显下降(P<0.01)。

    结论 观察乳腺癌的病理生物学特征可以预测预后、指导术式选择和综合治疗方案。

    【关键词】 乳腺癌；病理生物学特征；多因素分析；预后

    Breast cancer with pathobiology features for prognosis relation

    CHEN Guo-qing,XU Ying-jie,XIE Jiang,et al.

    Department of Surgery,ST.Luke’s Hospital,Shanghai 200050,China

    【Abstract】

    Objective To study the influence of pathobiology features on prognosis of breast cancer.

    Methods 704 patients with female breast cancers who had been operated from Jan,1995 to Dec,2004 were analyzed retrospectively and relation between the pathobiology features and statistical was examined.

    Results Their 5-year survival rate was 82.2%,there was no statistically significant difference(P>0.05),the distribution of cancer were no prognosis.Pathological staging was negatively correlated with prognosis.Size of tumor was positively correlated with axillary lymph node involvement and negatively correlated with survival rate.5-year survival rate was dramatic decreased of axillary lymph node positive breast cancer(P<0.01). ......