【摘要】 目的 结合动态血压监测(ABPM)方法综合评价卡维地洛与美托洛尔对轻、中度高血压的降压效应。 方法 78例高血压患者随机分为卡维地洛组(n=39)和美托洛尔组(n=39)。分别给予卡维地洛(25～50mg/d，每日1次)和美托洛尔(100～200mg/d，每日2次)，治疗12周。观察服药前及服药后12周末的24h、白昼、夜间及各时点的动态血压变化及谷/峰比。 结果 卡维地洛组和美托洛尔组服药前、服药治疗后12周末的24h、白昼、夜间的平均收缩压、舒张压明显下降，差异有显著性(P<0.05或<0.01)。卡维地洛组服药后12周末各时点收缩压、舒张压较服药前明显下降，差异有显著性(P<0.05)。美托洛尔组服药后12周末各时点收缩压、舒张压较服药前下降，但服药后的第23～24h血压下降不明显(P>0.05)。两组治疗后平均收缩压(SBP)和平均舒张压(DBP)的谷/峰比(T/P值)分别是63%/57%，和59%/51%。 结论 卡维地洛可维持24h平稳降压;美托洛尔仅能维持22h内血压下降;两者均有满意的谷/峰比。

    【关键词】 卡维地洛;美托洛尔;动态血压监测

    Comparison of the efficacy of carvedilol and metoprolol in patients with essential hypertension

    WANG Jie-ping，DU Xue-ping，YANGMing，et al.

    The Center of Cardiology，The Affiliated Fuxing Hospital，The Capital Medical University，Beijing100038，China

    【Abstract】 Objective To compare the clinical efficacy of twoβ-adrenoreceptor antagonists(carvedilol and meto-prolol)in the treatment of essential hypertension using ambulatory blood pressure monitoring(ABPM).Methods Sev-enty-eight patients with essential hypertension were enrolled in the study.The patients were randomly divided into carvedilol group(n=39)and metoprolol group(n=39).carvedilol group was given carvedilol(25～50mg/d)and Metoprolol group was given Metoprolol(100～200mg/d)for12weeks.To observe the changes of blood pressure of24h ......