【摘要】目的评价低蛋白饮食加α-酮酸(开同)治疗慢性肾功能不全合并继发性甲状旁腺亢进的疗效。方法选择30例慢性肾功能不全合并继发性甲状旁腺亢进患者，肌酐200～700μmol/L，用低蛋白饮食加α-酮酸治疗3个月，每天蛋白质摄入量0.6g/kg，开同4～8片/d，观察生化指标：肌酐、尿素氮、全段甲状旁腺激素、血钙、血磷、碱性磷酸酶、HCO-3等治疗前后的变化。结果治疗第1个月患者的全段甲状旁腺激素、血磷等有所下降，治疗3个月时下降更显著。结论低蛋白饮食加α-酮酸能有效治疗慢性肾功能不全合并继发性甲状旁腺功能亢进。

    关键词:低蛋白饮食;α-酮酸;甲状旁腺素;慢性肾功能不全

    Effect of low-protein diet plus α-ketonic acid on parathyroid hormone in chronic renal failure

    Sun Min,Lu Wenjun,Sheng Weiwen,et al.

    Department of Nephrology,Huadong Hospital of Shanghai,Shanghai 200040.

    【Abstract】ObjectiveTo appraise the effect of low protein diet plus α-ketonic acid in the treatment of chronic renal failure complicated with secondary hyperparathyroidism.Methods30 patients with chronic renal failure complicated with secondary hyperparathyroidism ......