【摘要】 目的 探讨茜草对衰老模型小鼠心肌线粒体的抗氧化作用。 方法 通过建立D-半乳糖人工致衰小鼠模型，测定心肌线粒体超氧化物歧化酶(SOD)，Na + -K + -ATP酶和Ca 2+ -ATP酶的活性及丙二醛(MDA)的含量。 结果 茜草能提高衰老模型小鼠心肌线粒体SOD，Na + -K + -ATP酶和Ca 2+ -ATP酶活性(P<0.05，P<0.01)，显著降低MDA的含量(P<0.01)。 结论 茜草能提高衰老模型小鼠心肌线粒体的抗氧化能力，具有一定的抗衰老作用。

    【关键词】 茜草 心肌线粒体 氧化损伤

    Protective effect of Rubia cordifolia L on oxidative damage to myocardial mitochondria of ageing model mice

    Xie Hong，Jiang Xudong，Wang Mingfu

    Department of Boichemistry，Medical College of Chinese People's Armed Police Forces，Tianjin300162.

    【Abstract】 Objective To observe the anti-oxidation effect of Rubia cordifolia L on myocardial mitochondria of senile mouse models.Methods The senile mouse models induced by D-Gal(galactose)were prepared and given water extract of Rubia cordifolia L for30days.We tested the activities of superoxide dismutase(SOD)，Na + -K + -ATPase and Ca 2+ -ATPase，and the content of MDA in myocardial mitochondria of senile mouse models.Results The Rubia cordifolia L enhanced the activities of SOD ......