【摘要】目的探讨抗心磷脂抗体(ACA)和急性冠脉综合征(ACS)的关系及其引起急性冠脉综合征的机制。方法64例ACS患者及50例健康体检者分别用ELISA和免疫透射比浊法测定血清ACA-IgG、ACA-IgM、ACA-IgA和TC、TG、HDl、apoA-I、apoB的含量。结果急性冠脉综合征组的ACA-IgG水平明显高于正常对照组(P<0.01)，而ACA-IgG变化的水平与TG呈显著正相关(r=0.31，P<0.01)，与 HDL、apoA-I改变呈显著的负相关(r=-0.36、-0.28，P均<0.01)。结论血清ACA-IgG是急性冠脉综合征的独立的致病因素，并通过血脂对急性冠脉综合征的发生、发展起作用。

    关键词:急性冠脉综合;征抗心磷脂抗体

    Relationship of serum lipid and changes of anticardiolipin antibody in acute coronary syndrome patients

    Zhao Xiaohui,Zhao Guizhi

    Department of Cardiovascular Medicine,First Hospital Affiliated to Jiamusi University,Jiamusi 154002.

    【Abstract】ObjectiveTo investigate the relationship of the levels of serum anticardiolipin antibody (ACA) to acute coronary syndrome(ACS),and to study the formative mechanism that ACA effects on ACS.Methods64 patients were divided into AMI group,UAP group and 50 normal individuals as control group.Blood samples were collected from 40 UAP,24 AMI and 50 healthy controls.The serum ACA-IgG,ACA-IgM,ACA-IgA were tested by ELISA.Serum lipid were measured by radio-immuno assay.A logistic regression was used to analyze the results.ResultsThe levels of serum lipid in AMI and UAP patients were higher than those in control group.ACA levels increased with TC ......