中药对环孢素A慢性肾毒性大鼠肾功能的保护作用
中草药,中草药;环孢素A;肾毒性;肾功能,1材料与方法,2结果,3讨论,【参考文献】
【摘要】 目的 观察养阴活血方药对环孢素A(CsA)慢性肾毒性大鼠肾功能的保护。 方法 将40只SD大鼠随机分为高剂量组、低剂量组、对照组及空白组,钠耗竭法建立CsA慢性肾毒性大鼠模型,分别以20倍成人剂量养阴活血方药、5倍成人剂量养阴活血方药、10倍成人剂量依那普利及自来水灌胃4周,分别于第1、2、3、4周末检测24h尿蛋白定量、血肌酐、肌肝清除率,并对各组结果进行比较。 结果 空白组24h尿蛋白定量4周后稍有上升,但差别无显著性(P>0.05)。对照组24h尿蛋白定量呈显著性下降(P<0.05),低剂量组治疗后24h尿蛋白定量亦呈下降趋势(P<0.05),高剂量组治疗4周后24h尿蛋白定量降低较低剂量组明显,但差别无显著性(P>0.05);空白组治疗后血肌肝呈上升趋势但差别无显著性(P>0.05)。对照组及高、低剂量组治疗后第4周血肌酐值较第1周有明显下降,差别均有显著性(P<0.05)。对照组及高、低剂量组与空白组治疗后差别有非常显著性(P<0.01)。空白组治疗后肌酐清除率无明显变化(P>0.05),对照组及高、低剂量组治疗后肌酐清除率呈上升趋势,差别无显著性(P>0.05)。 结论 中药养阴活血方对CsA慢性肾毒性大鼠的肾脏功能有一定的保护作用。【关键词】 中草药;环孢素A;肾毒性;肾功能
Chinese herbs medicine's protection on the renal function of chronic nephrotoxic-ity of cyclosplorine A(CsA)in rats
ZHOU Sheng,LUYou-quan,LIU Zhou,et al.
Nanhai Jinsha Hospital,Foshang City,Guangdong528223,Chi-na
【Abstract】 Objective To observe the protection of Chinese herbs medicine of nourishing yin and promoting blood circulation on chronic nephrotoxicity of cyclosplorine A(CsA)in rats.Method 40SD rats were divided into the high dosage group,low dosage group,control group and blank group randomly.The model were set up by salt depletion.The high dosage group was gastric injected with20times dosage herbas of nourishing yin and promoting blood circula-tion that the person taken while the low dosage group5times.The control group was gastric injected with10times dosage enalapril that the person taken.The blank group was treated by gastric infusion of water.The blood specimen and24hours urine was collected at the weekend of1st ......
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