【摘要】 目的 观察单用阿司匹林和联用前列腺素E 1 治疗老年不稳定型心绞痛(UAP)的临床疗效。 方法 将102例UAP患者随机分为对照组(阿司匹林)及治疗组(阿司匹林+前列腺素E 1 )。疗程为7～10天。 结果 疗程结束后总有效率:治疗组为94.23%，对照组为66.00%(P<0.05)。观察4周治疗组无一例发生急性心肌梗死，对照组发生2例(4.00%)。治疗组未发现明显不良反应。 结论 在常规治疗基础上加用前列腺素E 1 ，能更有效地控制心绞痛发作，降低心肌梗死发生率。

    关键词 阿司匹林 前列腺素E 1 不稳定型心绞痛

    Prostaglandin E 1 and aspirin versus aspinrin alone in unstable angina pectoris

    Zhang Jinmin，Wang Shangchun，Zhang Xinsheng，et al.

    Shanghai University Hospital，Shanghai200436.

    【Abstract】 Objective To compare the effects of PGE 1 and aspirin versus aspirin alone on transient myocar-dial ischemia and in-hospital prognosis in patients with unstable angina pectoris(UAP).Methods A total of66pa-tients with UAP were randomized into a group receiving aspirin(ASP group)，a group receiving aspirin plus PGE 1 (PGE 1 group)for two weeks.Results The effective rate was94.23%in the PGE 1 group and66.00%in the aspirin group after two weeks(P<0.05).No acute myocardial infarction occurred in the treating group.Two cases had acute myocardial infarction in the aspirin group after four weeks.No obvious adverse reaction was observed in the PGE 1 group.Conclusion Treatment with aspirin plus PGE 1 is more efficient than aspirin alone during the acute stage of UAP.Treatment with PGE 1 is efficient ......