【摘要】 目的 探讨结肠癌患者组织中血管内皮生长因子(vascular endothelial growth factor，VEGF)的表达水平与结肠癌侵袭和转移的关系。 方法 应用ELISA法对42例结肠癌、40例结肠良性肿瘤组织检测VEGF含量，按良恶性、肿瘤大小、临床分期等分别进行对照分析。 结果 结肠癌组织VEGF水平与结肠良性肿瘤组及正常结肠组比较，差异均有显著性(P<0.01);结肠癌淋巴结转移组患者组织VEGF表达水平与未转移组相比，差异有显著性(P<0.05);组织VEGF表达水平还与肿瘤大小和临床分期密切相关，VEGF含量随分期升高而逐步升高。 结论 VEGF可能在结肠癌浸润和转移过程中发挥重要作用，检测组织VEGF水平对预测结肠癌的侵袭和转移具有重要的临床意义。

    【关键词】 结肠肿瘤;血管内皮生长因子;转移

    Clinical significance of vascular endothelial growth factor in the tissue of colon cancer

    QUMu-wen，YANG Jing-guo.

    Department of General Surgery，Beijing Puren Hospital，Beijing100062，China

    【Abstract】 Objective To investigate the significance of the relationship between the expression of vascular en-dothelial growth factor(VEGF)in the tissue and invasion and metastasis in colon carcinomas.Methods The levels of VEGF in the tissue were detected by ELISA in42cases of colon carcinoma and40cases of benign colon tumor.The differences were compared between benign and malignant diseases ......