UGT1A8基因多态与结直肠癌的相关性
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王 敏, 孙德峰, 李延青, 陈 建, 郭辰虹
结直肠癌;葡萄糖醛酸转移酶1A8;多态性;易感性,王敏,孙德峰,李延青,陈建,刘福国,袁孟彪,郭辰虹,通讯作者,:,PolymorphismofUDP-g
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王敏, 山东大学齐鲁医院干部保健科 山东省济南市 250012
孙德峰,山东省烟台护士学校遗传教研室 山东省烟台市 264000
李延青,陈建,刘福国, 袁孟彪, 山东大学齐鲁医院消化内科 山东省济南市 250012
郭辰虹,山东大学医学遗传学研究所 山东省济南市 250012
王敏, 女,1968-08-22生,山东省烟台市人,汉族,山东大学齐鲁医院消化内科博士,主要从事结肠癌的基础与临床研究.
国家自然科学基金资助项目,No. 30370634
通讯作者:李延青,250012, 山东省济南市文化西路107号,山东大学齐鲁医院消化内科. doctorminmin@163.com
电话: 0531-82169454
收稿日期:2005-05-31 接受日期:2005-06-13
Polymorphism of UDP-glucuronosyltransferase UGT1A8 gene in humancolorectal cancer
Min Wang, De-Feng Sun, Yan-Qing Li, Jian Chen, Chen-Hong Guo, Fu-Guo Liu,Meng-Biao Yuan
Min Wang, Department of Health Care, Qilu Hospital of ShandongUniversity, Jinan 250012, Shandong Province, China
De-Feng Sun, Yantai Nursing School, Yantai 264000, ShandongProvince, China
Yan-Qing Li, Jian Chen, Fu-Guo Liu, Meng-Biao Yuan, Department ofGastroenterology, Qilu Hospital of Shandong University, Jinan 250012,Shandong Province, China
Chen-Hong Guo, Institute of Medical Genetics, Shandong University,Jinan 250012, Shandong Province, China
Supported by National Natural Science Foundation of China, No.30370634
Correspondence to: Yan-Qing Li, Department of Gastroenterology,Qilu Hospital of Shandong University, 107 Wenhua Road, Jinan 250012,Shandong Province, China. doctorminmin@163.com
Received: 2005-05-31 Accepted:2005-06-13
Abstract
AIM: To explore the relationship between the polymorphism ofUDP-glucuronosyltransferase UGT1A8 gene and human colorectal cancer (CRC).
METHODS: One hundred and nine cases of colorectal cancer and normalcontrols (NC), respectively, were collected for analysis. Genomic DNA wasprepared from full blood samples. The amplification of UGT1A8 exon-1sequences was performed using exon-1 specific primer. And the productswere visualized by gel electrophoresis and the fragments were purified ......
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