HMGCR基因多态性与乙型病毒性肝炎关联分析
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邓春青, 邓国宏, 王宇明
HMGCR基因;多态性;乙型病毒性肝炎,邓春青,邓国宏,王宇明,邓春青,通讯作者:,Relationshipbetweenpolymorphismso
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邓春青, 邓国宏, 王宇明, 第三军医大学西南医院感染科 重庆市 400038
邓春青, 女, 1970-03-05生, 汉族, 山西省临汾市人, 1990年山西医科大学学士, 副主任医师, 2003年第三军医大学西南医院感染科博士生, 主要从事乙型肝炎遗传易感性研究.
国家自然科学基金资助项目, No. 30200234
通讯作者: 王宇明, 400038, 重庆市沙坪坝区高滩岩正街30号, 中国人民解放军第三军医大学西南医院全军感染病研究所.
wym417@mail.tmmu.com.cn
收稿日期: 2005-04-04 接受日期: 2005-04-09
Relationship between polymorphisms of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene and
hepatitis B virus infection
Chun-Qing Deng, Guo-Hong Deng, Yu-Ming Wang
Chun-Qing Deng, Guo-Hong Deng, Yu-Ming Wang, Institute of Infectious Diseases, Southwest Hospital, the Third Military Medical UniversityChinese PLA, Chongqing 400038, China
Supported by National Natural Science Foundation of China, No. 30200234
Correspondence to: Yu-Ming Wang, Institute of Infectious Diseases, Southwest Hospital, the Third Military Medical University Chinese PLA, 30 Gaotanyan Zhengjie, Chongqing 400038, China. wym417@mail.tmmu.com.cn
Received: 2005-04-04 Accepted: 2005-04-09
Abstract
AIM: To investigate the relationship between exon20 polymorphism of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) gene and clinical outcome of the patients infected with hepatitis B virus (HBV).
METHODS: From the year 2002 to 2004 in Chongqing, the clinical data and blood samples of 2 400 patients with liver diseases were collected. The total DNA was extracted from the blood samples. After amplification, the exon20 polymorphisms of HMGCR gene (locus 18109T/C) were detected polymerase chain reaction (PCR), digestion of restriction enzyme and gel electrophresis.
RESULTS: A total of 1 354 patients were diagnosed with hepatitis B. Hardy-Weinberg equillibrum test showed a favorable goodness for fit (P = 0.016>0.01). Significant differences of genotypes and allele frequency existed between the asymptomatic carriers (AsCs) and patients of any other subgroup except acute hepatitis B and liver cancer (P <0 ......
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