【摘要】 目的 探讨早期应用纳洛酮对重型颅脑损伤患者内皮素及神经功能的影响及意义。 方法 采用按随机配对实验法，将82例重型颅脑损伤患者分为纳洛酮治疗组和对照组，在伤后不同时间予GCS评分、血ET测定、运动功能积分、及GOS预后评定。 结果 纳洛酮治疗组的各项指标均较对照组明显改善，两组差异有显著性(P<0.05)。 结论 早期应用纳洛酮治疗重型颅脑损伤，具有改善脑血流、脑代谢，保护脑细胞，改善脑干的缺血缺氧状态，从而利于神经功能恢复，并明显改善预后。

    【关键词】 纳洛酮;重型颅脑损伤;内皮素;神经功能

    Effect of early naloxone on endothelin and neurologic with severe traumatic brain injury

    CHEN Xu，HUANG Zhi-xiong，GUAN Guo-liang，et al.

    Department of Neurosurgery，The People's Hospital of Nanhai，Guangdong528200，China

    【Abstract】 Objective To study the effect of early naloxone on endothelin and neurologic with severe traumatic brain injury.Methods 82patients with diffuse severe cranial injury were randomly divided into two groups:treatment with naloxone groups and control group.The GCS score，plasma ET levels，were measured at different time after injury.Results The guideline of the treatment with naloxone groups were superior to those in the control group.Two results have significant differences(P<0.05).Conclusion An early dosage of naloxone can improve brain blood stream and metabolize ......