【摘要】 目的 探讨在控制超排卵(controlled ovarian hyperstimulation,COH)用药中,高剂量黄体生成素(luteinising hormone,LH)在卵泡的不同时期对体外受精—胚胎移植(in-vitro fertilization and embryo transfer,IVF-ET)的影响。方法 采用回顾性研究。常规方案实施IVF-ET的病人359例，按COH中卵泡刺激素(follicle-stimulating hormone,FSH)和LH的不同用量，以及用药时间分为3组：A组(n=252)，FSH≥225u/d，且LH≤225u/d(对照组)。B组(n=43)为卵泡晚期高LH接触组，FSH>225u/d，且取卵前3日内LH>225u/d(高LH近期组)。C组(n=64)卵泡早、中期高LH接触组，FSH>225u/d，且取卵前4日或以前LH>225u/d，取卵前3日内LH<225u/d(高LH远期组)。对各组受精率、胚胎植入率、临床受孕率、继续妊娠率进行比较分析。结果 A组的胚胎植入率、临床受孕率、继续妊娠率均高于B组(10.4%与7.0%,26.7%与18.4%,20.2%与9.5%，P<0.05);而与C组比较则差异无显著性(10.4%与9.5%,26.7%与23.6%,20.2%与18.6%，P>0.05),但受精率差异显著(60.2%与50.4%,P<0.05)。C组的胚胎植入率、临床受孕率与B组差异无显著性(9.5%与7.0%,23.6与18.4%,P>0.05)，但C组的继续妊娠率明显高于B组(18.6与9.5,P<0.05)。结论 降调节下COH应用LH>225u/d时，可使IVF-ET的受精率下降。在卵泡晚期(取卵前3日内)高LH的不良影响较大，其植入率、临床受孕率、继续妊娠率均明显下降。

    【关键词】 体外受精—胚胎移植；控制超排卵；黄体生成素；妊娠率

    The effect of follicle-phase related high-dose of LH on the outcome of patients undergoing IVF-ET

    XU Wen,LU Wei-ying,MA Yan-lin,et al.

    Hainan Medical University,Haikou 570102,China

    【Abstract】 Objective To examine the effect of high-dose luteinising hormone(LH)used in different folliclar phases as an option of treatment for patients undergoing controlled ovarian hyperstimulation of In-vitro Fertilization and Embryo ransfer(IVF-ET).Methods A retrospective study of 359 patients of IVF-ET,who used follicle stimulating hormone(FSH)more than one day with a dose exceeding 225u/day in their IVF-ET cycle.The fertility rates,implantation rates,clinical pregnancy rates and ongoing pregnancys rates were analyzed.The patients were divided into three groups according to dose of LH and the time used:group A(n=252),the control group,with FSH≥225u/day ......