【摘要】 目的 分析弥漫性腱鞘巨细胞瘤(D-TGCT)的临床和病理学特点及最佳治疗方式。方法 对7例经手术和病理确诊的D-TGCT的临床特征、病理和治疗进行了回顾性分析。结果 D-TGCT临床表现为近关节区逐渐长大的浅表软组织肿块，病理主要由单核细胞组成，并见散在的多核巨细胞和含铁血黄素沉积，免疫组化：CD68、α1-AT、Vimentin和溶菌酶阳性；S-100、EMA和CD34阴性，7例均接受手术和放疗，1例复发。结论 D-TGCT呈浸润性生长，手术后辅以放疗是减少复发的关键。

    【关键词】 腱鞘；巨细胞瘤；诊断；治疗

    The clinical study of diffuse-type tensoynovial giant cell tumor

    JIANG Wu-zhong,LIAO Yu-ping,WU Hai-jun,et al.

    Central South University Xiangya Hospital,Changsha 410008,China

    【Abstract】 Objective To investigate the clinical and pathological feature as well as the best way of treatment of diffuse-type tensoynovial giant cell tumor (D-TGCT).Methods 7 cases affirm actively diagnozed as D-TGCT through surgery and pathologic tests were retrospectively analyzed in regard to their clinical presentation,pathologic tests and treatments.Results Slowly growing tumor near the arthrosis was the clinical feature of D-TGCT. Histologic analysis showed a prominent mononuclear cell infiltrate,multinucleated giant cells,foamy macrophages, intra-and extracellular hemosiderin deposits. Immunohistochemical study showed that tumor cells were positive for vimentin,CD68,α1-AF and lysozyme; but negative for S-100,EMA and CD34. ......