冠心病心绞痛合并高脂血症患者血液高凝状态的观察
高凝状态,,心绞痛；高脂血症；高凝状态,1对象与方法,2结果,3讨论,【参考文献】
【摘要】 目的 观察高脂血症合并冠心病心绞痛患者凝血及纤溶系统的改变与血栓形成的关系。方法 分别采用双抗体夹心法和高效液相法对20例稳定型心绞痛(SAP)、26例不稳定型心绞痛(UAP)、22例高脂血症、24例高脂血症+SAP，21例高脂血症+UAP患者及20例健康人的血浆 von Willebrand因子(vWF:Ag)、血小板α-颗粒膜蛋白(GMP-140)、血浆D-二聚体(D-Dimer)水平以及尿纤维蛋白肽 A(UFPA)进行了检测。结果 结果显示不同类型的心绞痛、高脂血症及高脂血症+SAP和高脂血症+UAP患者上述指标均发生不同程度的改变，与对照组比较差异有显著性(P均<005)。结论 心绞痛和高脂血症及高脂血症+SAP和高脂血症+UAP患者体内存在有不同程度的血栓形成倾向。【关键词】 心绞痛；高脂血症；高凝状态
The observation on hypercoagulable state of coronary heart disease and hyperlipidemia
CHEN Bing-xue,WANG Ling-ling,LIU Li,et al.
PLA Bethune’s Medical College,Shijiazhuang 050081,China
【Abstract】 Objective To explore the relations and mechanisms on hypercoagul atble state of coronary heart disease(angina pectris ) and hyperlipidemia. Methods The levels of plasma von Willebrand factor(vWF:Ag),GMP-140,D-Dimer were determined by double-biotin-system ELISA and Urine Fiberinopeptide A(UFPA) by Ion chromatagraphy in hospitalized patients (20 stable angina pectris SAP;26 unstable angina pectris UAP;20 hyperlipidemia;24 hyperlipidemia +SAP; 21 hyperlipidemia +UA and 20 nomal controls).Results The result shows that there are significant changes in the patients compared with controls(P<0.05).Conclusion The hypercoagulable state was exited in the patients with UAP,hyperlipidemia +SAP and hyperlipidemia +UAP,suggested that coronary heart disease (angina pectris) and hyperlipidemia might have a same pathogenesis of hypercoagul ......
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