肿瘤坏死因子-a、细胞间黏附分子-1与扑热息痛肝损害
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田 丰, 王 颖, 吴作艳, 王学清, 李 岩
扑热息痛;肝损害;肿瘤坏死因子-a;细胞间黏附分子-1,田丰，王颖，吴作艳，王学清，李岩，,田丰,通讯作者：,电话：,收稿日期：,接受日期：,A
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田丰，王颖，吴作艳，王学清，李岩，中国医科大学附属第二医院(盛京医院)消化科 辽宁省沈阳市 110004
田丰, 男, 1972-01-06生, 辽宁省沈阳市人, 汉族, 2000年中国医科大学硕士研究生, 博士在读, 讲师, 主治医师, 主要从事肝脏疾病研究.
通讯作者：李岩, 110004, 辽宁省沈阳市和平区三好街36号, 中国医科大学附属第二医院(盛京医院)消化科. liyan99@medmail.com.cn.
电话：024-83956416
收稿日期：2005-08-05 接受日期：2005-08-26
Association of tumor necrosis factor-a and intercellular adhesion molecule-1 with acetaminophen-induced liver damages
Feng Tian, Ying Wang, Zuo-Yan Wu, Xue-Qing Wang, YAN Li
Feng Tian, Ying Wang, Zuo-Yan Wu, Xue-Qing Wang, Yan Li, Department of Gastroenterology, the Second Affiliated Hospital of Chinese Medical University, Shenyang 110004, Liaoning Province, China
Correspondence to: Yan Li, Department of Gastroenterology, the second Affiliated Hospital of Chinese Medical University, Shenyang 110004, Liaoning Province, China. liyan99@medmail.com.cn
Received: 2005-08-05 Accepted: 2005-08-26
Abstract
AIM: To investigate the effect of tumor necrosis factor-a(TNF-a) and intercellular adhesion molecule-1 (ICAM-1)on the acetaminophen-induced liver damages.
METHODS: The Sprague Dawley(SD) rat model of acetaminophen-induced liver damages was established using acetaminophen(AAP). The rats were killed at 3, 6, 12, and 24 h after the administration, respectively. The activity of serum alanine aminotransferase(ALT) was detected in the rats, and the pathological changes of the liver were observed by hematoxylin and eosin(HE) staining under light microscope. The level of serum TNF-a was examined by radioimmunoassay, and the expression of ICAM-1 mRNA in the liver tissues was measured by reverse transcription polymerase chain reaction(RT-PCR).
RESULTS: Twenty four hours after AAP administration, the level of serum TNF-a in AAP group was significantly higher than that in the controls (5.69 ± 0.46 µg/L vs 2.64 ± 0.27 µg/L, P <0.01), and it was positively related to the level of serum ALT (r = 0 ......
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