血小板活化因子对幼鼠肠道免疫屏障功能的影响
http://www.100md.com
王丽杰, 刘冬妍, 孙 梅, 赵 恂
血小板活化因子;肠道免疫屏障;幼鼠,王丽杰,孙梅,刘冬妍,赵恂,通讯作者：,电话：,传真:,收稿日期：,接受日期：,Effectofplateleta
 |
| 第1页 |
参见附件(409KB，3页)。
王丽杰, 孙梅, 中国医科大学附属第二临床学院儿科 辽宁省沈阳市110004
刘冬妍, 中国医科大学附属第二临床学院检验科 辽宁省沈阳市 110004
赵恂, 中国医科大学实验技术中心二部 辽宁省沈阳市 110001
通讯作者：王丽杰, 110004, 辽宁省沈阳市和平区三好街36号, 中国医科大学附属第二临床学院儿科. wlj682002@yahoo.com.cn
电话：024-23255060 传真: 024-83955509
收稿日期：2005-08-03 接受日期：2005-08-10
Effect of platelet activating factor on function of intestinal immunological barrier in young rats
Li-Jie Wang, Dong-Yan Liu, Mei Sun, Xun Zhao
Li-Jie Wang, Mei Sun, Department of Pediatrics, the Second Affiliated Clinical College, China Medical University, Shenyang 110004, Liaoning Province, China
Dong-Yan Liu, Department of Medical Examination, the Second Affiliated Clinical College, China Medical University, Shenyang 110004, Liaoning Province, China
Xun Zhao, the Second Department of Experimental Technique Center, China Medical University, Shenyang 110001, Liaoning Province, China
Correspondence to: Li-Jie Wang, Department of Pediatrics, the Second Affiliated Clinical College, China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. wlj682002@yahoo.com.cn
Received: 2005-08-03 Accepted: 2005-08-10
Abstract
AIM: To investigate the effect of platelet activating factor (PAF) on the content of secretory IgA (SIgA) in intestinal mucosa.
METHODS: The rats were intraperitoneally injected with different concentrations of PAF (50 and 65 µg/kg) at a dose of 1 µL/g. Double antibody-PEG radioimmunoassay was used to determine the amount of SIgA in the intestinal mucosa. The histological changes were detected by hematoxylin and Eosin staining under light microscope.
RESULTS: In the PAF65 group, the histological examination showed edema of the villus, capillary congestion of the lamina propria, extension of the subepithelial lymphatic channel, polymorphonuclear infiltration in enteric cavity, and shedding of the epithelial layer at 0 ......
您现在查看是摘要介绍页，详见PDF附件(409KB，3页)。