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慢性丙型肝炎患者 CD4+CD25+ 调节性T细胞表达增
http://www.100md.com 杨江华,张永祥,苏 川,孙南雄
HCV;CD4+CD25+Treg细胞;CD4+T细胞;Foxp3,慢性丙型肝炎患者CD4+CD25+调节性T细胞表达增加,杨江华,张永祥,孙南雄,,杨江华,通讯作者:,共同通讯作者:,Increa
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     杨江华,张永祥,孙南雄,南京医科大学第一附属医院感染科 江苏省南京市 210029

    苏川,南京医科大学病原生物学系 江苏省南京市 210029

    杨江华, 男, 1972-11-28 生, 安徽省铜陵市人, 汉族, 2003年南京医科大学博士研究生, 主要从事丙型肝炎慢性化机制研究.

    江苏省现代病原生物学重点实验室开放课题,No. XDBY04002

    通讯作者:苏川, 江苏省南京市汉中路140号, 南京医科大学病原生物学系. chuansu@njmu.edu.cn

    电话:025-86862773 传真:025-86661318

    共同通讯作者:孙南雄, 210029, 江苏省南京市, 南京医科大学第一附属医院感染科. sun9876@126.com

    电话:025-83986144传真:025-83190852

    收稿日期:2005-05-30 接受日期:2005-06-13

    Increase of CD4+CD25+ regulatory T cells in peripheral blood of patients with chronic hepatitis C

    Jiang-Hua Yang, Yong-Xiang Zhang, Chuan Su, Nan-Xiong Sun

    Jiang-Hua Yang, Yong-Xiang Zhang, Nan-Xiong Sun, Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China

    Chuan Su, Department of Pathogenic Biology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China

    Supported by the Open Project from Pathogenic Biology Laboratory of Jiangsu Province, No. XDBY04002

    Correspondence to: Chuan Su, Department of Pathogenic Biology, Nanjing Medical University, Nanjing 210029, Jiangsu Province,China chuansu@njmu.edu.cn

    Co-correspondence to: Nan-Xiong Sun, Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. sun9876@126.com.

    Received: 2005-05-30 Accepted: 2005-06-13

    Abstract

    AIM: To investigate the role of CD4+CD25+ regulatory T cells in the immune responses of patients with chronic hepatitis C.

    METHODS: The number of CD4+CD25+ regulatory T cells in the peripheral blood of chronic HC patients was detected by flow cytometry. Then the CD4+CD25+ regulatory T cells were co-cultured with CD4+CD25-T cells, and their inhibitory effect was analyzed ......

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