草苁蓉乙醇提取物对二甲基亚硝胺诱导大鼠肝纤维化的治疗作用
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朴熙绪, 黄红果, 朴东明
草苁蓉;二甲基亚硝胺;肝纤维化,朴熙绪，黄红果，,朴东明，,朴熙绪，,通讯作者：,Therapeuticroleofethanolicextr
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朴熙绪，黄红果，延边大学医学院附属医院消化内科 吉林省延吉市133000
朴东明，延边大学医学院附属医院病理科 吉林省延吉市 133000
朴熙绪，男，1951-10-25生，吉林省双阳县人，朝鲜族，1978年白求恩医科大学本科毕业，1984年延边大学医学院硕士研究生，主任医师，主要从事肝脏疾病的基础与临床研究，发表论文60余篇.
吉林省卫生厅医学科研基金资助项目，No.114
通讯作者：朴熙绪，133000，吉林省延吉市局子街119号，延边大学医学院消化内科.piaoxixu1951@yahoo.com.cn.
电话：0433-2660061 传真：0433-2513610
收稿日期：2005-07-15 接受日期：2005-08-03
Therapeutic role of ethanolic extract of Boschniakia Rossica in dimethylnitrosamine-induced liver fibrosis in rats
Xi-Xu Piao, Hong-Guo Huang, Dong-Ming Piao
Xi-Xu Piao, Hong-Guo Huang, Department of Gastroenterology, the Affiliated Hospital of Medical College of Yanbian University, Yanji 133000, Jilin Province, China
Dong-Ming Piao, Department of Pathology, the Affiliated Hospital of Medical College of Yanbian University, Yanji 133000, Jilin Province, China
Supported by the Fund from Medical Scientific Research of Health Department of Jilin Province, No. 114
Correspondence to: Xi-Xu Piao, Department of Gastroenterology, the Affiliated Hospital of Medical College of Yanbian University, 119 Juzi Street, Yanji 133000, Jilin Province, China. piaoxixu1951@yahoo.com
Received: 2005-07-15 Accepted: 2005-08-03
Abstract
AIM: To study the effect of Boschniakia Rossica ethanolic extract (BREE) in rat liver fibrosis induced by dimethylnitrosamine (DMN).
METHODS: Hepatic fibrosis was induced by DMN administration intraperitoneally. Thirty-five male Wistar rats were randomly divided into three groups: normal control group (GA, n = 10), hepatic fibrosis model group (GB, n = 15) and BREE treatment group (GC, n = 10). From the 1st to 3rd wk, rats in GB and GC were treated with DMN (10 g/L) intraperitoneally in the first three days of each week, while rats in GA were treated with normal saline. From the 4th to 7th wk, rats in GC were treated with 50 g/L BREE (10 mL/kg) intragastrically each day, while rats in GA and GB were treated with normal saline ......
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