瘦素及硬脂酰 CoA 去饱和酶-1在高脂饮食大鼠非酒精性脂肪肝发病中的作用
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陆元善，范建高，方继伟，丁晓东，杨兆瑞
高脂饮食;非酒精性脂肪肝;罗格列酮;瘦素;硬脂酰CoA去饱和酶-1,瘦素及硬脂酰CoA去饱和酶-1在高脂饮食大鼠非酒精性脂肪肝发病中的作用,陆元善，,范建高，方继伟，丁晓东，,杨兆瑞,陆元善,通讯作者
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陆元善，上海交通大学附属第一人民医院检验科上海市 200080
范建高，方继伟，丁晓东，上海交通大学附属第一人民医院消化科上海市 200080
杨兆瑞，上海交通大学附属第一人民医院病理科 上海市 200080
陆元善，男，1965-06-10生，江苏泰县人，汉族，1998年上海医科大学硕士研究生，主任技师，主要从事血脂及其相关疾病研究.
通讯作者：陆元善，200080，上海市虹口区武进路85号，上海交通大学附属第一人民医院检验科.luyuanshan@126.com.
电话：021-63240090-4306 传真:021-63240825
收稿日期：2005-08-29 接受日期：2005-09-06
Roles of leptin and stearoyl-CoA desaturase-1 in pathogenesis ofnonalcoholic fatty liver disease induced by a fat-rich diet
Yuan-Shan Lu, Jian-Gao Fan, Ji-Wei Fang, Xiao-Dong Ding, Zhao-Rui Yang
Yuan-Shan Lu, Department of Laboratory, the First Affiliated People’s Hospital of Shanghai Jiaotong University, Shanghai 200080, China
Jian-Gao Fan, Ji-Wei Fang, Xiao-Dong Ding,Department of Gastroenterology and Hepatology, the First Affiliated People’s Hospital of Shanghai Jiaotong University, Shanghai 200080, China
Zhao-Rui Yang, Department of Pathology, the First Affiliated People’s Hospital of Shanghai Jiaotong University, Shanghai 200080, China.
Correspondence to: Yuan-Shan Lu, Department of Laboratory, the First Affiliated People’s Hospital of Shanghai Jiaotong University, 85 Wujin Road, Hongkou District,Shanghai 200080, China. luyuanshan@126.com
Received:2005-08-29 Accepted:2005-09-06
Abstract
AIM: To explore the roles of leptin and stearoyl-CoA desaturase-1 (SCD-1) in the formation of nonalcoholic fatty liver disease (NAFLD) induced by a fat-rich diet, and their responses after medication.
METHODS: Forty-two SD rats were divided into control, experimental, and therapeutic group. The rats in the experimental and therapeutic group were fed with a fat-rich diet to establish NAFLD model, and the rats in the therapeutic group were treated with rosiglitazone for 16 wk from the 9th week of the fat-rich diet. The concentration of serum leptin was measured by enzyme linked immunosorbent assay (ELISA) ......
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