解偶联蛋白-2在大鼠非酒精性脂肪肝中的表达
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顾小红，张云东，冯爱娟
非酒精性脂肪;解偶联蛋白-2;免疫组化;Westernblot,顾小红,张云东,冯爱娟,顾小红,通讯作者:,Expressionofuncoupl
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顾小红, 中国人民解放军第三军医大学大坪医院野战外科研究所消化科 重庆市 400042
张云东, 中国人民解放军第三军医大学大坪医院野战外科研究所神经外科 重庆市400042
冯爱娟, 北京军区白求恩国际和平医院干部一科 河北省石家庄市050082
顾小红, 女，1968-06-01生，四川省绵阳盐亭县人，汉族，2004年第三军医大学在读博士，现任副主任医师，副教授，发表论文30多篇，参编专著7部，主要从事肝炎发病机理研究.
重庆市科学基金应用基础研究项目，No.8108
通讯作者: 顾小红，400042，重庆市，中国人民解放军第三军医大学大坪医院野战外科研究所消化科.zhanggxh68@sina.com
收稿日期: 2005-08-01 接受日期: 2005-08-03
Expression of uncoupling protein 2 in nonalcoholic fatty liver of rats
Xiao-Hong Gu, Yun-Dong Zhang, Ai-Juan Feng
Xiao-Hong Gu, Yun-Dong Zhang, Department of Gastroenterology,Daping Hospital of the Third Military Medical University, Chongqing400042, China
Yun-Dong Zhang, Department of Neurological Surgery, DapingHospital of the Third Military Medical University, Chongqing 400042,China
Ai-Juan Feng, the First Department of Cadre, BaiqiuenInternational Peace Hospital of Beijing Military Compound, Shijiazhuang050082, Hebei Province, China
Supported by the Science Foundation of Chongqing for BasicApplicative Project, No.8108
Correspondence to: Xiao-Hong Gu, Department of Gastroenterology,Daping Hospital of the Third Military Medical University, Chongqing400042, China. zhanggxh68@sina.com
Received: 2005-08-01 Accepted: 2005-08-03
Abstract
AIM: To investigate the role of uncoupling protein-2 (UCP2) in thenonalcoholic fatty liver(NAFL) of rats.
METHODS: Sixty-four Wistar rats were randomly divided into twogroups: the control group and high-fat diet induced-fatty liver group.The expression of UCP2 antigen in the hepatocytes was examined byimmunohistochemistry and Western blot. Meanwhile, the levels of serumtriglyceride (TG), free fatty acid (FAA), and alanine aminotransferase(ALT)were measured by biochemical method.
RESULTS: The expression of UCP2 antigen and the number of UCP2positive cell were progressively increased at 2, 4, 8 and 12 wk, and thelevels of serum TG(0 ......
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