COX-2 在 Barrett食管和食管腺癌中的表达及意义
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刘心娟, 王邦茂, 阎雪燕,刘文天, 吕宗舜, 张
环氧合酶-2;Barrett食管;食管腺癌;前列腺素E2,COX-2在Barrett食管和食管腺癌中的表达及意义,刘心娟，,王邦茂，阎雪燕，刘文天，吕宗舜，张洁，,通讯作者：,Expressionof
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刘心娟，北京世纪坛医院消化科 北京市 100038
王邦茂，阎雪燕，刘文天，吕宗舜，张洁，天津医科大学总医院消化科 天津市 300052
刘心娟，女，1975-12-12生，河北省人，汉族，2002年天津医科大学硕士，住院医师，主要从事消化系统肿瘤的研究.
通讯作者：刘心娟，100038，北京市海淀区铁医路10号，北京世纪坛医院消化科.
电话：010-51896370
收稿日期：2005-05-13 接受日期：2005-06-30
Expression of COX-2 in Barrett’s esophagus andesophageal adenocarcinoma and its significance
Xin-Juan Liu, Bang-Mao Wang, Xue-Yan Yan, Wen-Tian Liu, Zong-Shun Lu, Jie Zhang
Xin-Juan Liu, Department of Gastroenterology, Beijing ShijitanHospital, Beijing 100038, China
Bang-Mao Wang, Xue-Yan Yan, Wen-Tian Liu, Zong-Shun Lu, Jie Zhang, Department of Gastroenterology, General Hospital of Tianjin MedicalUniversity, Tianjin 300052, China
Correspondence to: Xin-Juan Liu, Departmentof Gastroenterology, Beijing Shijitan Hospital, 10 Tieyi Road, HaidianDistrict, Beijing 100038, China
Received: 2005-05-13 Accepted: 2005-06-30
Abstract
AIM: To explore the significance of cyclooxygenase-2 (COX-2)expression and prostaglandin E2 (PGE2) level in human Barrett’sesophagus (BE) and esophageal adenocarcinoma (EAC).
METHODS: The expression of COX-2 mRNA, the distribution of COX-2protein, and the content of PGE2 were detected in the endoscopicbiopsies of from BE (n = 16), EAC (n = 17), and normalcontrols (n = 20) by reverse transcription polymerase chainreaction (RT-PCR), immunohistochemistry, and radioimmunoassay (RIA),respectively.
RESULTS: The positive rate of COX-2 mRNA was 87.50% (14/16) and88.24% (15/17) in BE and EAC patients, respectively, which weresignificantly higher than that in the normal controls (25%, P<0.01). Furthermore, COX-2 protein was expressed in the epithelialcytoplasm of BE patients (81.25%, 13/16) and the plasm of cancer cellsin EAC patients (76.47%, 13/17), which were significantly higher thanthat in the normal controls (20.00%, 4/20). The contents of PGE2 (pg/mg)in BE (541 ......
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