摘 要：目的：探讨单光子吸收法测定糖皮质激素对大鼠骨骼影响的骨密度。方法：16只3月龄♂ SD大鼠，体重345～347g，随机分为对照组和激素组，后者喂醋酸泼尼松4.5mg/kg，每周2次。3个月后，对两组动物的股骨进行骨密度测定。结果：与对照组比较，激素组大鼠股骨近段和中段的骨矿含量有减少的趋势；股骨三段的骨宽度有所增加；股骨近段、中段和远段骨密度分别减少了11.8%(P<0.05%)、12.5%(P<0.05)和10.5%(P<0.05)。结论：单光子吸收法除了能测定人体骨密度外，也可用于对大鼠骨质疏松的研究。

    关键词： 醋酸泼尼松； 骨质疏松； 骨密度； 单光子吸收法

    Effect of the Glucocorticoids on Bone Mineral Density of the Skeleton in Rats

    LI Wei-qun, LIU Chen-shu, et al

    (The Affiliated Hospital of Guangdong Medical College, Guangdong Zhanjiang 524001, China)

    Abstract： Objective: To explore Effect of the glucocorticoids on Bone mineral density of the skeleton in rats using the single photon absorptiometric measurements.Method: 16 male Sprague-Dawley(SD) rats at 3 months of age and weighing 345～347g were randomly divided into control and hormonal groups. The hormonal group was given prednisone acetate (4.5mg/kg,ig) two times a week. After 90 days, single photon absorptiometric measurements were made on femurs of 2 group rats. Result: The bone mineral density in proximal, middle and distal segments of femurs in hormonal rats was respectively decreased by 11.8%(P<0.05%)、12.5%(P<0.05) and 10.5%(P<0.05), in comparision to control group. Conclusion: The single photon absorptiometric measurements may also be used in osteoporotic study in rats. ......