摘要：目的:观察氯沙坦联合苯那普利对早期糖尿病肾病(DN)的临床疗效。方法:将60例2型糖尿病肾病患者随机分为两组,分别使用氯沙坦、苯那普利两药联用为治疗组(n=30),单用苯那普利为观察组(n=30)，疗程16周。观察两组治疗前后各组患者的平均动脉压(MAP)、尿白蛋白排泄率(UAER)、内生肌酐清除率(Ccr)、尿素氮(BUN)、空腹血糖(FBG )、糖化血红蛋白(HbA1C)、血脂等变化。结果: 治疗组与观察组对早期DN,均有明显降低血压、UAER和BUN的作用,各组在治疗前后具有明显差异(P<0.01或P<0.05);但治疗组效果更好,尤其降低UAER作用有明显差异(P<0.01);各组FBG、CH、TG治疗前及治疗后各组间比较无统计学意义(P>0.05)。结论: 氯沙坦联合苯那普利治疗早期糖尿病肾病疗效确切。

    关键词：糖尿病肾病；氯沙坦；苯那普利

    A study on Therapeutic Effect of Losartan Combined with Benazpril on Diabetienephropathy

    XU Hui-juan

    (Medical College of Jinhua Professional & Technological College, Zhejiang Jinhua 321000, China)

    Abstract：Objective: To observe the therapeutic effect of losartan combined with benazpril on diqabetienephropathy. ethods: The treatment group(n=30) was treated with losartan combined with benazpril while the observation one with benazpril alone; Both groups were observed for determination of MAP, UAER, CCr, BUN, FBG and HbAIC,etc before initiation of therapy and after treatment for 16 weeks. Results: Significant decrease was detected in blood pressure, UAER and BUN (P<0.01 or P<0.05); the treatment group’s decrease especially in UAER was more significant(P<0.01); little significance was detected in terms of FBG, CH and TG(P>0.05). Conclusion: Losartan combined with benazpril has definite therapeutic effect on early DN. ......