【摘要】 目的 评价幽门螺杆菌粪便抗原(HpSA)法在儿童幽门螺杆菌(Hp)感染的诊断价值。方法 分别应用HpSA法和细菌培养检测了78例因反复上腹痛、脐周痛等消化道症状的来医院就诊的儿童标本，并与细菌培养结果对比以判断其幽门螺杆菌感染情况。结果 与细菌培养结果相比，以HpSA法检测的78例患者中Hp 感染的阳性率为48.7%，其敏感性、特异性、阳性预测值、阴性预测值分别为94.6%、92.7%、92.1%、95.0%，二者结果差异无显著性(P>0.05)，准确性为93.6%。结论 HpSA法检测幽门螺杆菌感染是一种非侵入性的方法，方法简单方便，有高敏感性和特异性，具有良好的临床应用价值。

    【关键词】 幽门螺杆菌；粪便；抗原；诊断

    Helicobacter pylori antigen in stool in diagnosis of children infection

    WANG An-fang.

    Kang’ai Hospital,Nanjing 210029,China

    【Abstract】 Objective To evaluate the value of Helicobacter pylori antigen in stool (HpSA) in diagnosis of children Helicobacter pylor (Hp) infection.Methods 78 patients with symptoms of repeatedly upper abdominal or perinave pain were detected in stool specimens by HpSA and bacteria culture,the results compared with bacteria culture to evaluate the Hp status of children Hp infection.Results Positive ratio of Hp infection was 48.7% by detecting antigen in 78 subjects stool specimens.The test showed a sensitivity,specificity,positive predictive value and negative predictive value of HpSA test for the 78 patients were 94.6%,92.7%,92.1%,95.0% respectively,and the accuracy was 93.6%.Conclusion Stool antigen method showed a good sensitivity,specificity and accuracy for diagnosing Hp infection in children.This novel method may be useful in clinical practice as a basic test because it is rapid,reliable easy to perform and a high sensitivity,specificity,accurate,noninvasion test. ......