摘要：目的：研究香菇多糖协同阿糖胞苷(Ara-c)对HL-60白血病细胞增殖力的影响。方法：观察HL-60细胞，分别经香菇多糖、Ara-c或香菇多糖协同Ara-c处理后，HL-60活性、抑制率及集落形成能力的变化，并与对照组(不含处理因素)比较。结果：香菇多糖协同Ara-c组HL-60细胞集落形成能力、增殖抑制率与其他三组比有显著差异，HL-60细胞活力与Ara-c组比无显著差异；香菇多糖组与对照组比各项指标均无显著差异。结论：香菇多糖能增强Ara-c对HL-60细胞的杀伤力。

    关键词: 香菇多糖；Ara-c；HL-60；杀伤力

    The Effects of Lentinan Polysaccharide and Ara-c on theAbility of HL-60 Cells Proliferation

    WU Dong-hong, WANG Cui-lian, ZHANG Yu-ming, et al

    (Affiliated Hospital of Guangdong Medical College, Guangdong Zhanjiang 524001, China)

    Abstract： Objective:To study the effects of lentinan polysaccharide and Ara-c in the ability of proliferation on HL-60 cells. Method:Observing the activity, inhibited-rate and the colony-formation-ability of the HL-60 cells in lentinan polysaccharide-Ara-c group, lentinan polysaccharide group, Ara-c group and control group. Result: The differences in colony-formation-ability and inhibited-rate of the HL-60 cells between lentinan polysaccharide-Ara-c group and the other three groups were significant, but there is no difference in the activity when the former compared with the Ara-c group,also there is no difference between lentinan polysaccharide group and control group in each parametes. Conclusion:Lentinan polysaccharide helps to enhance the ability of Ara-c in killing the HL-60 cells. ......