α-细辛脑-β-环糊精包合物的制备及体外溶出度测定
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文章编号：(2003)04-0150-06,α-细辛脑-β-环糊精包合物的制备及体外溶出度测定
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刘 宇，王东凯 (沈阳药科大学药学院，辽宁 沈阳 110016)
摘要：目的 研究α-细辛脑-β-环糊精包合物的制备方法及包合前后α-细辛脑物理性能变化情况。方法 采用研磨法制备α-细辛脑-β-环糊精包合物，运用正交试验法优选最佳制备工艺，测定了α-细辛脑及α-细辛脑-β-环糊精包合物的溶解度和溶出度，并比较了二者的X-射线衍射图谱、红外光谱、紫外光谱的变化，以验证包合物的形成。结果 最佳制备工艺条件为α-细辛脑与β-环糊精为1: 6(m:m)，β-环糊精与水为1:1.5(m:V)，α-细辛脑与乙醇为1: 3(m:V)，研磨时间为90 min；α-细辛脑经β-环糊精包合后，溶解度为原药的5.31倍，α-细辛脑及包合物的溶出度参数t50分别为46.2、18.9 min，经红外光谱、紫外光谱、X-射线衍射图谱确证了包合物的形成。结论 α-细辛脑被β-环糊精包合后呈现出新的物相特征，为α-细辛脑加工成各种剂型开辟良好的前景。
关键词：药剂学；β-环糊精包合物；研磨法；α-细辛脑
中图分类号：R96 文献标识码：A
Preparation of inclusion complex of α-asarone-β-cyclodextrin and their dissolution in vitro
LIU Yu，WANG Dong-kai
(School of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016,China)
Abstract: Objective To study the preparation method of the inclusion complex of α-asarone-β-cyclodextrin and the physical property changes of α-asarone before and after being included by β-cyclodextrin. Methods The inclusion complex of α-asarone-β-cyclodextrin was prepared by trituration method; the preparation process was optimized by orthogonal experiments; the dissolution and solubility of the α-asarone and the α-asarone-β-cyclodextrin were determined respectively, and the formation of the inclusion complex was indentified by comparing the X-ray diffraction spectrum, IR, UV of them ......
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