纳米颗粒的修饰及其在医药领域的应用
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文章编号：(2004)06-0144-09,纳米颗粒的修饰及其在医药领域的应用
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高 萍，张向荣，徐 晖, 王绍宁， 姬雅菊， 郑俊民，陈大为
(沈阳药科大学 药学院，辽宁 沈阳 110016)
摘要：目的 综述纳米颗粒的修饰及其应用。方法 根据纳米颗粒靶向机理的不同进行分类总结，概述聚合物纳米颗粒修饰的研究进展；对纳米技术在临床诊断和监测、治疗、药物制剂等领域的应用进行综述。结果与结论 纳米颗粒的修饰可改善其长循环和靶向作用；目前纳米颗粒在医药领域获得广泛应用。
关键词：药剂学；修饰；综述；纳米颗粒；应用
中图分类号： R94 文献标识码：A
Modification and application in pharmaceuticals
GAO Ping, ZHANG Xiang-rong, XU Hui, WANG Shao-ning, JI Ya-ju, ZHENG Jun-min，CHEN Da-wei
(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)
Abstract: Objective To review the recent advances on the surface modification and application of polymeric nanoparticles. Methods The recent advances on the modification of polymeric nanoparticles were summarized according to different targeting mechanism; and its application in clinical diagnosis, clinical therapy and pharmaceutics etc. were discussed in details. Results and Conclusions The modification can improve the long-circulation and targeting properties of nanoparticles; Nanoparticles are widely used in biomedical and pharmaceutical fields.
Key words: pharmaceutics; surface modification; review; nanoparticles; application
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