吲哚拉新多晶型的制备及溶解度的研究

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     王 晶，袁 悦, 王 岩

    (沈阳药科大学 药学院 辽宁 沈阳 110016)

    摘要：目的 考察δ型吲哚拉新在不同温度和不同pH值磷酸盐缓冲溶液中的溶解度，并与α晶型进行比较。方法 通过溶解度的测定计算溶解焓，推测药物的稳定性。结果 在pH 6.8时, α型和δ型吲哚拉新的溶解焓分别为105 J·mol^-1和16.6 J·mol^-1。结论 溶解焓小的δ型溶解度大，晶型的稳定性差。

    关键词：药剂学；多晶型；溶解度；吲哚拉新；溶解焓

    中图分类号：R913 文献标识码：A

    Study on the preparation and solubility determination of polymorphs of indolacin

    WANG Jing ,YUAN Yue , WANG Yan

    (School of Pharmacy , Shenyang Pharmaceutical University, Shenyang 110016,china)

    Abstract：Objective Solubility of δ-type crystalline form of indolacin in phosphate buffer solution with various pH were determined at various temperatures, compared with that of α-type crystalline form. Method The enthalpy of solution of indolacin was calculated by determining solubility to predict its stability. Results The enthalpy of solution α-type and δ-type crystalline form were 105 J·mol^-1 and 16.6 J·mol^-1, respectively in buffer solution with pH 6.8. Conclusion Indolacin in δ-type crystalline form with small molar enthalpy of solution has high solubility and poor stability.

    Key words： pharmaceutics；polymorphs ；solubility；indolacin；solution enthalpy

    http://www.100md.com/html/DirDu/2005/10/19/78/33/40.htm

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