对乙酰氨基酚包衣缓释微丸的制备和体外释放研究
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蔡翠芳1，包 宇2，毕殿洲1
(1.沈阳药科大学药学院,辽宁 沈阳 110016；2.东北制药总厂制剂销售处，辽宁 沈阳 110026)
摘要：目的 以甲基丙烯酸树脂Eudragit®NE30D作为包衣材料，制备对乙酰氨基酚包衣缓释微丸。方法 采用滚动凝聚法制备了对乙酰氨基酚素丸，采用包衣锅滚转法对素丸进行包衣制备缓释微丸。 用释放度测定法考察影响药物释放的各种影响因素。结果 包衣增重和致孔剂用量是影响药物释放的关键因素，所制微丸具有明显的缓释特性 。结论 以甲基丙烯酸树脂Eudragit®NE30D作为包衣材料所得缓释微丸符合12 h缓释要求。
关键词：药剂学；包衣缓释微丸；滚动凝聚法；对乙酰氨基酚； 水分散体；甲基丙烯酸树脂
中图分类号：R 943 文献标识码：A
Studies on the preparation and in vitro release of acetaminophen sustained-release pellets coated with Eudragit®NE30D
CAI Cui-fang1, BAO Yu2,BI Dian-zhou1
(1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. The Northeast General Pharmaceutical Factory Sales Department，Shenyang 110026,China)
Abstract: Objective To prepare sustained-release pellets coated with Eudragit®NE30D. Methods The effects of process variables and formulation variables on pellets drug release were investigated. Results The sustained-release coated pellets had a marked sustained-release property. Conclusions it is possible to prepare sustained-release pellets coated with aqueous dispersion Eudragit®NE30D.
Key words: pharmaceutics；rolling-cohesion spheronisation；coated sustained-release pellets ; acetaminophen; aqueous dispersion; Eudragit®NE30D
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