α­细辛脑自微乳化释药系统的处方筛选

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     史朝晖¹ 王东凯¹ 刘 莱¹ 徐 飒²

    (1.沈阳药科大学 药学院，辽宁 沈阳 110016，2.沈阳沃森药物研究所， 辽宁 沈阳 110016)

    摘要：目的 研究α­细辛脑自微乳化释药系统的处方。方法 通过假三元相图和粒径分析进行处方筛选。在假三元相图中分别以油酸乙酯和Myglyol812N为油相，以吐温80和Cremophor EL为乳化剂，以PEG400和Labrasol为助乳化剂，通过自微乳化区域比较，初步确定3个处方；再进一步通过粒径分析，以最小粒径的处方为最佳处方。结果 最佳处方组成为m(油酸乙酯):m(吐温80):m(PEG400) = 20:60:20，其中药物含量的质量分数为6%。结论 可以将α­细辛脑制成自微乳化释药系统。

    关键词：药剂学；自微乳化释药系统；假三元相图法；α­细辛脑

    中图分类号：R94 文献标识码：A

    Formulation study of the self-microemulsifying drug delivery system of α­asarone

    SHI Zhao-hui¹ ,WANG Dong-kai¹，LIU Lai¹，XU Sa²

    (1.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China，2.Shenyang Watson Pharmaceutical Institute,Shenyang 110016, China)

    Abstract: Objective To study the self­microemulsifying drug delivery system(SMEDDS) of α­asarone. Method Formulations were screened by the pseudo­ternary phase diagrams and the analysis of droplet size. In the study of pseudo­ternary phase diagrams, ethyl oleate and Myglyol812N were selected as oil phase, Tween80 and Cremophor EL as surfactants, PEG400 and Labrasol as co-surfactants, respectively. Three formula were determined primarily by the comparison of self-microemulsifying area. Further more, the best formula was obtained by droplet size analysis. Result The optimized formulation was composed of ethyl oleate­Tween80­PEG400 = 20∶60∶20, including 6% α­asarone. Conclusion α­asarone could be made into self­microemulsifying drug delivery system .

    Key words pharmaceutics; self­microemulsifying drug delivery system; pseudo­ternary phase diagrams; α­asarone

    http://www.100md.com/html/DirDu/2005/10/19/78/35/42.htm

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