正交试验法优化吴茱萸巴布剂的基质配方

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     张 蓓¹，王东凯¹，高 红¹，张印策²

    (1.沈阳药科大学 药学院，辽宁 沈阳 110016；2.沈阳沃森药物研究所,辽宁 沈阳 110016)

    摘要： 目的 研究吴茱萸巴布剂的最优配方。 方法 采用正交试验，以基质的黏着力为指标进行吴茱萸巴布剂基质最优处方的筛选。 结果 优化的基质配方为m(吴茱萸浸膏): m(皂土): m(甘油): m(质量分数为 0.5 %的聚乙烯醇): m (聚丙烯酸钠) = 20.0 : 6.0 : 20.0 : 40.0 : 3.5。 结论 优化处方具有良好的涂展性、保湿性且黏着力适中。

    关键词：药剂学；吴茱萸；巴布剂；基质配方；正交设计法；黏着力

    Study on matrix formulation of cataplasm of Rutaecartu

    ZHANG Bei¹, WANG Dong-kai¹, GAO Hong¹, ZHANG Yin-ce²

    (1 .School of Pharmacy, Shenyang Pharmaceutical University ,Shenyang 110016 , China; 2 .Shenyang Watson Pharmaceutical Institute, Shenyang 110016, China)

    Abstract: Objective To choose the optimum formulation of cataplasm of Rutaecartu. Method Orthogonal design was used to select the matrix formulation of cataplasm of Rutaecartu , with the appearance, viscosity , spreadability, and residual as the index in the experiment. Results The optimum proportion of extractum of Rutaecartu ,bentonite , glycerin , 0.5% polyvinyl alcohol and poly sodium acrylate is 20:6:20:40:3.5. Conclusion The optimum formulation is of moderate viscosity with good spread and humectant properties.

    Key words: pharmaceutics; Rutaecartu; cataplasm; matrix formulation; orthogonal design; adhesive force

    http://www.100md.com/html/DirDu/2005/10/19/78/39/41.htm

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