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编号：10792870
膀胱移行细胞癌中Pgp、p53、GSTπ、Bcl2的表达与多药耐药性
http://www.100md.com 《新疆医科大学学报》 2005年第9期
膀胱,,膀胱肿瘤；移行细胞癌；免疫组化；多药耐药性,1资料与方法,2结果,3讨论,参考文献:
     摘要：目的：探讨膀胱移行细胞癌中P糖蛋白(Pgp)、p53、Bcl2、谷胱甘肽S转移酶π(GSTπ)的表达，了解多药耐药性与膀胱移行细胞癌细胞凋亡的相关性。方法：采用链霉素生物素(SP)免疫组化技术检测75例膀胱移行细胞癌和10例无病变膀胱(正常对照组)标本Pgp、p53、GSTπ、Bcl2的表达。结果：膀胱移行细胞癌中Pgp、p53、GSTπ、Bcl2的阳性表达率分别为82.66%、69.33%、80.00%、65.33%；不同病理分级膀胱移行细胞癌中Pgp、GSTπ、Bcl2的阳性表达差异有统计学意义(P<0.05~0.01),不同病理分期膀胱移行细胞癌中Pgp、GSTπ、p53、Bcl2阳性表达差异有统计学意义(P均<0.05)；复发病例中Pgp、GSTπ表达异常与p53、Bcl2之间存在联系。结论：Pgp、p53、Bcl2、GSTπ等表达与膀胱移行细胞癌的分期有关；Pgp、GSTπ高表达在膀胱移行细胞癌中是一种常见现象；耐药指标Pgp、GSTπ与凋亡指标p53、Bcl2影响因素有一定的内在联系。

    关键词：膀胱肿瘤；移行细胞癌；免疫组化；多药耐药性

    Relationship between multidrug resistance of expression and Pgp, p53, GSTπ，Bcl2 protein expression in ransitional cell carcinoma of human bladder

    WANG Qing, ZHANG Yu, NI Zecheng, et al

    (Department of Urology, The People’s Hospital of Xinjiang Uigur Autonomous Region,Urumqi 830000, China)

    Abstract：Objective: This study was designed to investigate the relationship between pathology and Pgp, p53, GSTπ, Bcl2 expression in the grade of differentiation and stage of differentiation of transitional cell carcinoma of the bladder and relationship between multidrug resistance of expression. Methods: Using SP method of immunohistochemical analysis for expression of Pgp, p53, GSTπ and Bcl2. Results: Pgp, p53, GSTπ, Bcl2 protein expression in transitional cell carcinoma of the human bladder from 75 patients showed 82.66%, 69.33%, 80.00%, 65.33% respectively. Pgp, GSTπ, p53 and Bcl2 showed different expression in different stages and grades. Following up expression p53 and Bcl2, protein expression, Pgp, GSTπ affect were obviously changed. Conclusions: p53, Bcl2 of apoptosis parametres and GSTπ, Pgp multidrug resistance of parametres in transitional cell carcinoma of the human bladder, both were obviously associated with the stage of differentiation and the grade of differentiation. Multidrug resistance Pgp, GSTπ could affect apoptosis protein expression p53, Bcl2. ......

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