金因肽治疗60例难愈性创面临床观察
金因肽,,金因肽；难愈性创面；治疗,1资料与方法,2结果,3讨论,参考文献：
摘要：目的: 观察金因肽治疗乳腺癌术后残余创面、烧伤合并糖尿病病人植皮后创面、烧伤后残余创面的临床疗效。方法： 116例乳腺癌术后残余创面、烧伤合并糖尿病病人植皮后创面、烧伤残余创面随机分为2组，金因肽治疗组60例，采用金因肽喷洒创面，外敷一层磺胺嘧啶银霜纱布；磺胺嘧啶银霜治疗组56例，采用1%磺胺嘧啶银霜涂抹创面厚约0.2 mm，外用无菌敷料包扎，观察2组的创面愈合时间及有无局部刺激性、有无过敏反应、致热作用。 结果： 金因肽治疗组、磺胺嘧啶银霜治疗组治疗乳腺癌术后残余创面平均愈合时间分别为15.2、23.4 d，烧伤合并糖尿病病人植皮后创面平均皮片红润时间分别为3、6 d，烧伤后残余创面平均愈合时间分别为7、21 d。金因肽治疗组治疗后各创面均无局部刺激性、过敏反应、致热作用。结论： 金因肽有促进难愈创面愈合的作用，无明显毒副作用。关键词： 金因肽；难愈性创面；治疗
The clinical observation of applying rhEGF to treat refractory surface of wounds
ZHANG Feng, DENG Dawei
(Department of Surgical Oncology, Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China)
Abstract: Objective： To observe the clinical effects of recombinant human epidermal growth factor (rhEGF) on the surface of wound after therapy for breast cancer, the surface of wound after the skingrafting for the patients with diabetes and remaining surface of wound after burning. Methods: One hundred and sixteen patients with the refractory surface of wound. were divided two groups randomly. 60 patients were treated by rhEGF, and other 56 patients were treated by “SDag”. In the rhEGF group: to spray the rhEGF on the wounds ,then cover the gauze with sulfadiazine silver cream. The SDag group: to cover 1% sulfadiazine silver cream for about 0.2 mm on the wounds and bind up with the germfree dressing. To compare the recovering time of the wound. At the same time, to observe whether it had partly thrill or not and whether it had hyper susceptibility and heating effect after comparison. Results: For the surface of wound after therapy for breast cancer, the average recovering time with “rhEGF” and “SDag” was different, The former need 15.2 d, and the latter need 23.4 d. For the burned person and the patients with drabets after the skingrafting the wound average with “rhEGF” and “SDag” were 3 d and 6 d respectively. And the average recovering time of the refractory wounds, such as the remaining wound after burning with “rhEGF” and “SDag” was very different, too. The former need 7 d, the latter 21 d. Both the difference of recovering time and the rubicund time of the piece of skin in two groups had statistic significances (P<0.01). There were thrill, hyper susceptibility and bring about fever on the wounds after treated with “SDag”. But there was no such cases on the wounds after treated with “rhEGF”. Conclusion: “rhEGF” has the obverious effect which can cure refractory wounds and without side effect. ......
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