αadducin基因变异与哈萨克族原发性高血压的关系
基因,,αadducin基因；,Gly460Trp多态性；,原发性高血压；哈萨克族,1资料与方法,2结果,3讨论,参考文献:
摘要: 目的: 探讨αadducin基因的Gly460Trp多态性与新疆伊犁地区哈萨克族人原发性高血压的关系。方法： 313例新疆伊犁地区哈萨克族人分为2组，原发性高血压组201例，正常对照组112例，采用突变分离多聚酶链反应(MSPCR)分析技术，检测2组αadducin基因的Gly460Trp多态性。 结果： 原发性高血压组、正常对照组的αadducin基因Gly460Trp位点的Gly/Gly、 Gly/Trp、 Trp/Trp 3种基因型频率分别是24.88%、49.25%、25.87%和25.89%、47.32%、26.79%, 2组相比差异无统计学意义(P>0.05)。原发性高血压组、正常对照组的460Gly、460Trp等位基因频率为49.50%、50.50%和49.55%、50.45%，2组相比差异无统计学意义(P>0.05)。结论： 新疆伊犁地区哈萨克族人αadducin基因的Gly460Trp多态性与其原发性高血压无关联。关键词： αadducin基因； Gly460Trp多态性； 原发性高血压；哈萨克族
The relationship between the αadducin gene variant and essential hypertension in Kazaks
LI Hongjian, LI Nanfang, ZHOU Ling, et al
(Department of Cardiovascular Medicine, Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, China)
Abstract: Objective: To investigate the relationship between the Gly460Trp polymorphism of αadducin gene and essential hypertension in Kazak in Yili of Xinjiang. Methods: 313 Kazaks were divided into 2 groups, 201 were in essential hypertension group, 112 in control group .Mutagenically separated polymerase chain reaction (MSPCR) methods were used to detect the Gly/Trp polymorphism of αadducin gene in 313 Kazaks. Results: The Gly/Gly, Gly/Trp and Trp/Trp genotype frequencies were 24.88%, 49.25% and 25.87% respectively; 460Gly and 460Trp allele frequencies were 49.50% and 50.50% respectively in essential hypertension group. While the corresponding frequencies were 25.89%, 47.32%, 26.79%； 460Gly and 460Trp allele frequencies 49.55% and 50.45% respectively in control group. There was no significant difference in 460Trp/Trp genotype and 460Trp allele of αadducin gene between hypertension and control groups(P>0.05). Conclusions: It is concluded that there is lack of association between the variant of αadducin gene and essential hypertension in Kazak in Yili of Xinjiang. ......
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