兔耳_____增生性瘢痕；_兔耳动物模型；

兔耳增生性瘢痕动物模型的建立与应用

http://www.100md.com 《新疆医科大学学报》 2005年第8期

兔耳,,增生性瘢痕；,兔耳动物模型；,外科感染常见致病细菌,1材料与方法,2结果,3讨论,参考文献：

     摘要: 目的: 观察外科感染常见致病细菌对兔耳腹侧创面愈合后增生组织块形成的影响。方法: 在兔耳腹侧制作72个直径为1 cm的圆形全层皮肤缺损创面，待其愈合后形成增生性瘢痕组织块作为兔耳增生性瘢痕动物模型，进行形态学和组织学观察。另选同等大小兔耳腹侧240个创面，将其随机分成对照组和实验组，实验组又分为金黄色葡萄球菌污染组、大肠杆菌污染组、绿脓杆菌污染组,观察各组创面愈合情况与增生块发生等情况。结果：人为造成兔耳腹侧创面后可出现类似人增生性瘢痕的增生组织块，出现率为66.7%;4组平均愈合时间分别为(13.367±1.025)d、(19.283±1.091)d、(13.967±0.948)d、(16.233±0.981)d，实验组与对照组比较差异有统计学意义(P<0.01)；4组增生块出现率分别为64%、90%、75%及80%。金黄色葡萄球菌污染组增生块出现率与对照组比较差异有统计学意义(P<0.05)；各组创面愈合时间与增生块出现率呈正相关(r=0.169， P<0.01)。结论: 增生性瘢痕兔耳动物模型制作简单,模型稳定,重复性强，可作为人增生性瘢痕形成机制与防治研究的动物模型；外科感染常见致病细菌可延长兔耳创面愈合时间,增加兔耳创面愈合后增生块的出现率是促进增生性瘢痕形成的重要因素。

    关键词：增生性瘢痕；兔耳动物模型；外科感染常见致病细菌

    Establishment and application of experimental animal model for hypertrophic scar

    ZHOU Qinsheng, MA Shaoling, DONG Xianglin

    (Department of Plastic Surgery, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China)

    Abstract：Objective：To observe the effect of B.Pathogenesis of surgical infection on the formation of hypertrophic scar in rabbits ears after injury. Methods： Fullthickness excisional wounds, 1 cm in diameter,were created over the ventral surface of ears in 6 adult New Zealand white rabbits and then excisional wounds healed, which was called animal model of rabbit ear for hypertrophic scar. Wound healing models were established on 20 adult rabbit ears, according to methods mentioned above,which were randomly divided into control group(group A) Staphylococcus aureus group(group B) E.coli group(group C) P.aeruginosa group(group D) and were observed wound healing time of group A, B, C and D incidence of forms of hypertrophic scar. Result：Hypertrophic dermal scars with some clinical and histologic on rabbits ears are similar to that in human hypertrophic scar and its incidence was 66.7%. The mean values of wound healing time of group A, B, Cand D were (13.367±1.025) d, (19.283±1.091)d, (13.967±0.948)d, (16.233±0.981) d respectively, which have statistical differecnce. Incidence of hypertrophic dermal scar of group A, B, C and D were 64%, 90%, 75%, 80% respectively. Both group B and group A were found to have statistical differecnce. The mean values of wound healing time of group A, B, C and D are positively relative with incidence of forms of scar. Conclusion：The establishment of animal model of rabbit ear for hypertrophic scar is simple, stable and repeated experiment method for formationing mechanism and preventive study of human hypertrophic scar. B. Pathogenesis of surgical infection extend healing time and increase forms of hypertrophic scar incidence in rabbits ears,which may be considered an important promoting factor in formation of hypertrophic scar. ......

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