特发性肺纤维化患者血清Ⅲ型前胶原和层粘连蛋白测定的临床意义
层粘连蛋白,,Ⅲ型前胶原；,层粘连蛋白；,肺疾病，,间质性,1资料与方法,2结果,3讨论,参考文献:
摘要： 目的： 探讨特发性肺纤维化(IPF)患者血清Ⅲ型前胶原(PCⅢ)和层粘连蛋白(LN)水平与临床病情程度的关系。方法： 对29例已确诊的IPF患者进行呼吸困难程度调查、拍摄常规胸片、检查血气及运动肺功能后得出临床影像生理(CRP)评分，根据CRP评分系统将患者分为低分组、高分组，与健康对照组同时测定血清PCⅢ和LN水平，并对各组PCⅢ、LN水平进行比较。结果： (1)CRP评分与PCⅢ测量值作等级相关分析,相关系数rs′=0.723 8(P<0.01)，呈正相关关系。低分组与对照组血清PCⅢ水平相比差异无统计学意义(P=0.582 3)，高分组与对照组、低分组相比差异均有统计学意义(P<0.01)。(2) CRP评分与LN测量值作等级相关分析，相关系数rs′=0.622 7(P<0.05)，呈正相关关系。血清LN水平低分组与对照组相比差异有统计学意义(P<0.01)，高分组与低分组相比差异有统计学意义(P<0.01)。结论： 应用CRP评分系统可评估IPF患者病情程度，血清PCⅢ及LN水平可作为评价肺间质病变活动性的重要的无创性指标。关键词： Ⅲ型前胶原； 层粘连蛋白； 肺疾病， 间质性
Clinical value of type Ⅲ procollagen peptide and laminin in serum of idiopathic pulmonary fibrosis
LIU Hui, XI Hui, WANG Huiwu, et al
(Department of Respirology, First Affiliated Hospital, Xinjiang Medical University,Urumqi 830054, China)
Abstract: Objective: To explore clinical value of type Ⅲ procollagen peptide PCⅢ and laminin in serum of patients with idiopathic pulmmary fibrosis. Methods: A composite clinicalradiographicphysiologic(CRP) scoring system was cited, 29 patients with idiopathic pulmonary fibrosis were divided into 2 groups according to CRP scoring system: low score group, high score group. The serum concentrations of PCⅢ and laminin were measured in patients and the control group. Results: The CRP score determination correlated with the serum concentration of PCⅢ (r=0.723 8, P<0.01), The PCⅢ of high score group was significantly higher than that of control group (P<0.001), and was significantly higher than that of low score group (P<0.01). The CRP score showed a significant correlation with the concentration of LN (r=0.622 7, P<0.05). Conclusion: Serum concentrations of PCⅢ and LN in patients with idiopathic pulmonary fibrosis are important parameters in evaluating activity of interstitial lung involvement. ......
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