牙周炎_____白细胞介素6；龈沟液；牙周炎；绝经

绝经早期妇女龈沟液白细胞介素6 与牙周炎的关系

http://www.100md.com 《新疆医科大学学报》 2005年第3期

牙周炎,,白细胞介素6；龈沟液；牙周炎；绝经,绝经早期妇女龈沟液白细胞介素6与牙周炎的关系,1资料与方法,2结果,3讨论,参考文献：

     摘要：目的：探讨白细胞介素6(IL6)与绝经早期妇女牙周炎的关系。方法：选择30例非牙周炎和49例患慢性中、重度牙周炎的维吾尔族(维族)妇女，所有妇女绝经年限均≤5年。采集30颗牙周健康牙和49颗牙周炎患牙的龈沟液(GCF)样本，随后记录牙周临床观察指标。应用放射免疫分析法检测GCF中IL6的含量。结果：牙周健康组GCF中IL6的含量为(1 088.10±102.33) pg/ml,慢性牙周炎组GCF中IL6的含量为(2 961.22±224.80) pg/ml, 慢性牙周炎组明显高于牙周健康组(P<0.005)；经相关分析，慢性牙周炎患牙GCF中IL6的含量与GI、PPD、CAL均呈正相关(r=0.564, P<0.005; r=0.335, P<0.05; r=0.324, P<0.05)。结论：绝经早期的妇女健康牙GCF中含有少量IL6。GCF中IL6的产生增加可能与牙周炎的发生、发展有关，同时IL6的水平反映了牙周炎症的严重程度，可以尝试作为判断牙周病变程度的一个指标。

    关键词：白细胞介素6；龈沟液；牙周炎；绝经

    The association between Interleukin6 in gingival crevicular fluid(GCF) and periodontitis in early menopausal women

    Haliya, Adalaiti, Ayifuhan

    (Department of Stomatology, First Affiliated Hospital,Xinjiang Medical University,Urumqi 830054, China)

    Abstract：Objective：To analyze the association between GCF IL6 level and common clinical measurements of periodontitis in early menopausal women. Methods：Fortynine moderate/severe chronic periodontitis patients and 30 nonperiodontitis subjects, all Uyghur women within 5 years after menopause were enrolled in the study. 30 GCF samples were harvested from healthy sites of 30 nonperiodontitis subjects, 49 GCF samples from chronic periodontitis sites of 49 chronic periodontitis subjects. Clinical measurements of each tooth were recorded after obtaining GCF samples. GCF IL6 was measured by 125I radioimmunoassay (RIA). Results：The mean concentration of GCF IL6 from healthy sites was (1088.10±102.33) pg/ml. The mean concentration of IL6 from chronic periodontitis sites was (2961.22±224.80) pg/ml, significantly higher than that of healthy sites (P<0.005). Positive correlation was found between GCF IL6 level and clinical measurements (GI, PPD and CAL) (r=0.564, P<0.005; r=0.335, P<0.05; r=0.324, P<0.05). Conclusions：These findings suggest that there are lower IL6 in GCF from healthy sites of early menopausal women; the increasing production of IL6 may be associated with the initiation and progress of perodontitis. IL6 may be a valuable indicator of the severity of periodontitis. ......

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