摘要:目的 探讨混合核苷酸对刀豆蛋白A(Con A)所致肝损伤的保护作用。 方法 用Con A诱导小鼠肝损伤，用混合核苷酸灌胃治疗，3d后取血，检测血清ALT、AST活性和一氧化氮(NO)含量，检测肝组织超氧化物歧化酶(SOD)的活性和丙二醛(MDA)含量，并观察肝组织病理学变化。 结果 混合核苷酸大剂量组ALT、AST活性均明显低于模型组(P<0.01)，但与联苯双酯组比较，差异无显著性意义(P>0.05);混合核苷酸大、中剂量组肝组织SOD活性明显升高、MDA含量显著降低，与模型组比较，差异有显著性意义(P<0.05);混合核苷酸大、中、小剂量组血清NO含量较模型组明显降低(P<0.05);混合核苷酸中剂量组肝组织病理改变明显减轻。 结论 混合核苷酸对ConA所致小鼠肝损伤具有较好的保护作用，其保肝机制与抗脂质过氧化损伤和抑制NO的产生密切相关。

    关键词:混合核苷酸;刀豆蛋白A;肝损伤;一氧化氮;超氧化物歧化酶;丙二醛中图分类号:R575.1

    Protective effect of mixed nucleotide on liver injury in mice induced by concavalin A.LI Yue-mei 1 ，LI Xiang-yang 2 .(1.The First Affiliated Hospital of Guangzhou Traditional Medicine University，Guangzhou510405，Guangdong，P.R.China)

    Abstract:Objective To investigate the protective effects of mixed nucleotides on liver injury in mice induced by concanavalin A(Con A). Methods The model of liver injury induced by Con A was used for evaluating the therapeutic effects of Mixed nu-cleotides in mice.After3days of Mixed nucleotides was given to mice by gastric perfusion，their blood sample and liver tissue were taken ......