椒蒿挥发油_____椒蒿挥发油；免疫功能；动物实验

椒蒿挥发油对免疫低下小鼠免疫功能的影响

http://www.100md.com 《新疆医科大学学报》 2005年第4期

椒蒿挥发油,,椒蒿挥发油；免疫功能；动物实验,1材料与方法,2结果,3讨论,参考文献:

     摘要: 目的：探讨椒蒿挥发油对免疫低下小鼠免疫功能的调节作用。方法：选取BALB/c小鼠60只，随机分为正常对照组、环磷酰胺组(Cp)及椒蒿挥发油低、中、高(1.875、3.750，7.500%椒蒿挥发油 20 ml/kg)3个剂量组连续给药10 d，测定各组小鼠外周血白细胞数、腹腔巨噬细胞吞噬率数、细胞因子IL2、血清半数溶血值(HC50)及刀豆蛋白A(ConA)刺激的小鼠脾淋巴细胞增殖功能。结果：低、中、高3个剂量椒蒿挥发油给药组小鼠外周血白细胞数、腹腔巨噬细胞的吞噬率、HC50、血清IL2值均明显升高(P均<0.05 )；中、低剂量组可明显增强ConA诱导的脾淋巴细胞的增殖(P<0.05)。结论：椒蒿挥发油可增强小鼠的免疫功能，并对体液、细胞免疫功能有促进作用，提示椒蒿是一种免疫调节物。

    关键词：椒蒿挥发油；免疫功能；动物实验

    Effects of valatile oil from Artemsia dracunculus L. on immunological function in immunodepressed mice

    XIA Chunmei, GU Dantian, AN Changxin, et al

    (Department of Histology and Embryology, Xinjiang Medical university, Urumqi 830054, China)Abstract：Objective: The Effects of volatile oil from Artemsia dracunculus L. leaves on immunological function in immunodepressed mice induced by cyclophosphamide were studied. Methods: In order to detect the immunmodulatory effects of Artemsia dracunculus L. , the white blood cell counts in peripheral blood, the phagocytosis ability of Macrophage, the lymphocyte transformation (MTT methods), serum IL2, serum hemolysin concentration 50% were tested. Results: The results showed that volatile oil of Artemsia dracunculus L. at the dose of 7.5%, 3.75%,1.875% 20 ml/kg, can cause a signficant increase of WBC, phagocytic rate, and the serum IL2,serum hemolysin concentration 50% (P<0.05) the low and middle dose of extract of Artemsia dracunculus L. can cause a significant increase the transformation rate of the spleen lymphocytes, (P<0.05) in immunodepressed mice. Conclusions: volatile oil from Artemsia dracunculus L. can significantly enhance the nonspecific, cellmediated and humoral immunological function in immunodepressed mice. ......

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