大鼠原位肝移植动物模型的建立
移植,,肝；移植；大鼠；袖套法,1材料与方法,2结果,3讨论,参考文献：
摘要: 目的：建立稳定的大鼠原位肝移植模型，为移植免疫学研究提供动物实验技术平台。 方法：采用远交系Wistar和远交系SD大鼠，用二袖套一吻合法(门静脉和肝下下腔静脉行袖套法，肝上下腔静脉行吻合法)建立大鼠原位肝移植模型。 结果：共行大鼠原位肝移植30例次，其中WistarWistar大鼠移植20例次，大鼠6~7 d死亡，平均生存5.1 d。SDWistar大鼠移植10例次，大鼠4~5 d死亡，平均生存3.8 d。 结论: 二袖套一吻合法操作简便，手术成功率高，可作为肝移植试验的有效方法。关键词：肝；移植；大鼠；袖套法
The establishment of orthotopic liver transplantation in rat
LU Ming, MIAO Yuqing, ZHANG Jinhui, et al
(Department of General Surgery, First Affiliated Hospital, Xinjiang Medical University,Institute of Organ Transplantation in Xinjiang, Urumqi 830054, China)
Abstract：Objective: To make an ideal model for liver transplantation. Methods: TwoCuff (portal vein and infrahepatic vena cava) technique was applied in the production of this animal model in Wistar rats and SD rats. Results: With the modifiation, a successful rate of 83.3% was achieved in the production of the experimental model with anhepatic period of on average 19 minutes. Conclusion: The results show that the model is easily available and highly reproducible and can be used in the experiment of liver transplantation. ......
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