【摘要】 目的 奥美拉唑和西咪替丁治疗十二指肠溃疡病对其愈合率和复发率影响的对比研究。方法 53例经内镜检查证实的活动性十二指肠溃疡病，随机分成奥美拉唑组和西咪替丁组，先行短程治疗。奥美拉唑每日1次，每次20mg，治疗4周;西咪替丁每次800mg，每晚睡前服，治疗4～6周。结果 奥美拉唑组和西咪替丁组4周溃疡愈合率分别为92.3%(24/26例)和66.7%(18/27例)，西咪替丁组6周溃疡愈合率为85.2%(23/27例)。对溃疡愈合的47例进行长程治疗，前者用量是一次口服20mg，每周2次;后者是400mg，每晚睡前服一次;各用药一年，观察一年内溃疡累积复发率。复发均经内镜检查证实。奥美拉唑组一年内累积复发率为4.2%(1/24)，西咪替丁组为26.1%(6/23)。结论 推测奥美拉唑组短程治疗时溃疡愈合率高于西咪替丁组而长程治疗时一年累积复发率明显低于西咪替丁组，是奥美拉唑对酸抑制程度强和24h内抑制酸分泌的持续时间长的缘故。

    关键词 奥美拉唑 西咪替丁 十二指肠溃疡病

    Study of ulcer healing and relapse rate in patients with duodenal ulcer diaease

    Deng Hongli

    Department of Medicine Huizhou Da Ya Wan of West Section Hospital，Huizhou516001.

    【Abstract】 Objective Fifty-three patients with endoscopically proven active duodenal ulcer disease were randomly allocated to treat mentwith omeprazole and cimetidine.Methods Omeprazole was used in a dose of20rag p.o.daily and cimetidine800rag p.o.given as single dosing at bedtime for4weeks.Results At the end of the short-term treatment92.3%(24/26)of ulcers were healed with omcprazole vs66.7%(18/27)with cimetidine.Another five patients whose ulcers healed at6weeks were also included in the short-term cimetidine treatment group.After ulcer healing ......