血管紧张素Ⅱ1型受体(AT1R)基因多态性与新疆哈萨克族原发性高血压的相关性研究
血管紧张素Ⅱ1型受体,,血管紧张素Ⅱ1型受体；A1166C多态性；原发性高血压；哈萨克族,1材料与方法,2结果,3讨论,参考文献：
摘要: 目的：研究血管紧张素Ⅱ1型受体(AT1R)基因A1166C多态性与新疆哈萨克族原发性高血压(EH)的相关关系。方法： 采用多聚酶链式反应法及限制性片段长度多态性技术(PCR-RFLP)，对新疆哈萨克族198例EH患者(EH组)及130例正常血压者(对照组)的外周血白细胞DNA进行AT1R基因A1166C多态性检测，观察AA、AC和CC不同基因型以及该位点A、C不同等位基因频率在EH组和对照组中的分布。结果：AA、AC和CC基因型在EH组的分布频率为0.772 8、0.222 1和0.005 1，在对照组为0.761 5、0.238 5和0，两组对比差异无统计学意义(P>0.05)；A1166与C1166等位基因频率在高血压组中分别为0.883 8、0.116 2，对照组中分别为0.880 8和0.119 2，两组相比差异均无统计学意义(P>0.05)。结论：AT1R基因A1166C分子变异与新疆哈萨克族原发性高血压无相关关系。关键词：血管紧张素Ⅱ1型受体；A1166C多态性；原发性高血压；哈萨克族
The study for relationship between the polymorphism of angiotensin Ⅱ type 1 receptor gene A1166C and essential hypertension in kazak of XinjiangLI
Nanfang, LI Tao, ZHOU Ling, et al
(Hypertension Unit, The People′s Hospital of Xinjiang Uigur Autonomous Region,Urumqi 830001, China)
Abstract： Objective： To investigate the relationship between the A1166C allele polymorphism of angiotensinⅡ Type 1 Receptor (AT1R) gene and the essential hypertension in Kazak of Xinjiang. Methods： Polymerase chain reaction and restriction fragment length polymorphism (PCRRFLP) methods were used to detect the A1166C polymorphism of AT1R gene in Kazak including 198 patients with hypertension and 130 normotensive controls. Results: The genotype frequencies of A1166C were AA0.7728, AC0.2221 ......
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